Advisor - Isotopic Chemistry

At Lilly, the work is demanding because patients are waiting. We unite caring with discovery to help make life better for people around the world, knowing that every decision, every detail, and every day matters. Headquartered in Indianapolis, Indiana, our over 50,000 employees around the globe take on complex challenges to discover and deliver life-changing medicines, strengthen how health is understood and managed, and support the communities we serve. This is hard, urgent, selfless work—but it’s work worth doing. If you’re driven by purpose and ready to bring your best to work that truly matters for patients, we invite you to join us. 

City:  Indianapolis

State:  Indiana

Country:  United States

Region:  North America

Company overview:   At Lilly, we unite caring with discovery to make life better for people around the world. We are a global healthcare leader headquartered in Indianapolis, Indiana. Our 39,000 employees around the world work to discover and bring life-changing medicines to those who need them, improve the understanding and management of disease, and give back to our communities through philanthropy and volunteerism. We give our best effort to our work, and we put people first. We’re looking for people who are determined to make life better for people around the world.

The Isotopic Chemistry within our organization is responsible for support of ADME related activities by providing radiolabeled drug candidates for mass balance, metabolism, PK and transporter studies both in animals and in humans. The radiolabeled compounds are also required in early discovery for receptor binding/occupancy studies. Compounds labeled with stable isotopes are used as internal standards in the bioanalytical support of number drug development activities. The synthesis of putative metabolites is also in the scope of the Isotopic Chemistry.

We are looking for highly motivated, creative synthetic organic chemist with deep expertise, good communication skills, ability to work within wide variety of cross-functional teams, including metabolism scientists, ADME project leaders, clinical pharmacology scientists, biologists and chemists from drug discovery and CMC areas.

Your work will include development of new synthetic pathways for introduction of isotopic labels into molecules of drug candidates and tool compounds. You will provide scientific oversight and management of synthetic and radio-synthetic contract labs.

This role will require engaging in experimental design and data interpretation to deliver the discovery and development portfolio of investigational targets and novel therapeutics. We are passionate about making an impact in the lives of our patients. Consider joining our efforts!

Responsibilities: 

• Provide scientific oversight of synthetic projects and outsourced activities related to the preparation of isotopically labeled compounds and metabolites to ensure on-time delivery and high quality of compounds to support Lilly portfolio.

• Collaborate with Lilly’s chemists and design synthetic routes for introduction of radiolabels and stable isotope labels in the molecules of drug candidates.
• Work closely with ADME scientists on selecting metabolically stable position for radiolabeling.
• Interact with bioanalytical teams to outline synthetic target for compounds labeled with stable isotopes.
• Develop new synthetic methods for the preparation of putative metabolites.
• Partner with external CRO resources to implement design ideas of Isotopic synthesis.
• Work within clinical pharmacology and CMC teams to ensure delivery of radiolabeled compounds for human clinical trials.
• Prepare appropriate sections of IND for regulatory submission.
• Present at internal or external forums

 

 

Basic qualification:

• MS in Chemistry with 8 years' experience in Isotropic Chemistry
• Experience in radiochemistry and stable isotope chemistry

 

 

Additional skills/preferences:    

• PhD in Organic Chemistry
• Experience in drug discovery and development with preferable hands-on experience with Carbon-14 and/or Tritium
• Understanding principles pharmacokinetics and ADME.
• Ability to balance multiple projects and handle competing responsibilities.
• Demonstrate strong communication skills with the ability to integrate diverse perspectives, adroitly deliver critical messaging, and influence leaders/key partners.
• Collaborative team behaviors and aspiration to build and sustain relationships with R&D customers and the wider scientific community.

Additional information:  Lilly is an EEO/Affirmative Action Employer and does not discriminate on the basis of age, race, color, religion, gender, sexual orientation, gender identity, gender expression, national origin, protected veteran status, disability or any other legally protected status.

Lilly is dedicated to helping individuals with disabilities to actively engage in the workforce, ensuring equal opportunities when vying for positions. If you require accommodation to submit a resume for a position at Lilly, please complete the accommodation request form (https://careers.lilly.com/us/en/workplace-accommodation) for further assistance. Please note this is for individuals to request an accommodation as part of the application process and any other correspondence will not receive a response.

Lilly is proud to be an EEO Employer and does not discriminate on the basis of age, race, color, religion, gender identity, sex, gender expression, sexual orientation, genetic information, ancestry, national origin, protected veteran status, disability, or any other legally protected status.

Our employee resource groups (ERGs) offer strong support networks for their members and are open to all employees. Our current groups include: Africa, Middle East, Central Asia (AMECA), Black Employees at Lilly (BE@Lilly), Chinese Culture Network (CCN), EnAble, Evolve, Lilly Indian Network (LIN), Organization of Latinx at Lilly (OLA), Pride (LGBTQ+ Allies), Veterans Leadership Network (VLN) and Women’s Initiative for Leading at Lilly (WILL).

Actual compensation will depend on a candidate’s education, experience, skills, and geographic location.  The anticipated wage for this position is

$153,000 - $246,400

Full-time equivalent employees also will be eligible for a company bonus (depending, in part, on company and individual performance). In addition, Lilly offers a comprehensive benefit program to eligible employees, including eligibility to participate in a company-sponsored 401(k); pension; vacation benefits; eligibility for medical, dental, vision and prescription drug benefits; flexible benefits (e.g., healthcare and/or dependent day care flexible spending accounts); life insurance and death benefits; certain time off and leave of absence benefits; and well-being benefits (e.g., employee assistance program, fitness benefits, and employee clubs and activities).Lilly reserves the right to amend, modify, or terminate its compensation and benefit programs in its sole discretion and Lilly’s compensation practices and guidelines will apply regarding the details of any promotion or transfer of Lilly employees.

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