Principal Scientist, Medical Physicist

Life at BMS

At RayzeBio, every day is an opportunity to ignite meaningful change. As a wholly-owned subsidiary of Bristol Myers Squibb, RayzeBio blends the nimble, pioneering spirit of an emergent biotech with the global expertise and resources of a leading innovator in oncology. Our mission is to develop transformative radiopharmaceutical therapies that offer new hope for patients living with cancer. Here, you’ll join a multidisciplinary team where your ideas are valued, your expertise is amplified, and collaboration is at the heart of everything we do. From day one, expect to make an immediate impact—on our science, on our teams, and most importantly, on patients. Learn more about RayzeBio: https://careers.bms.com/rayzebio/

The Principal Scientist, Medical Physicist, will be responsible for applying their expertise in radiopharmaceutical (RPT)-specific modeling to the research and development of new drugs and therapies. Their focus will be on radiopharmaceutical dose modelling and analyzing data from in vitro and vivo studies as well as clinical diagnostic and therapeutic studies. The candidate will be responsible for leading translational dosimetry analysis such as physiologically based pharmacokinetics or compartmentalization modelling. The candidate will also provide technical support including dosimetry calculations and work in collaboration with internal stakeholders as well as external vendors and experts. 

Job Responsibilities

Essential duties and responsibilities include the following. Other duties may be assigned.

• Work closely with Radiation Biophysics/Medical Physics to support all aspects of internal dosimetry analysis in discovery and development of radiopharmaceutical imaging and therapeutic agents.
• Work closely with Discovery to design experiments and perform dosimetric data analysis from imaging modalities like PET (positron emission tomography) and SPECT (single-photon emission computed tomography) to assess drug uptake and distribution,
• Identify and advise best practices and standardization processes for image data quality control in preclinical research, aligned with current guidance in literature.
• Analyze preclinical and clinical imaging data to advance the translation of animal-to-human dose projection.
• Explore new technologies and modelling approaches to improve the development of radiopharmaceuticals, such as novel radioisotopes including alpha-emitters.
• Contribute to the advancement of medical physics knowledge in the field of radiopharmaceuticals.
• Provide technical support, training and problem-solving solutions to cross-functional teams as needed.
• Applies AI to improve team execution and decision‑making

Education and Experience

• Advanced degree in Medical Physics or Engineering (PhD preferred) with didactic training in RPT biodistribution, kinetics and dose modelling.
• Minimum of 6 years of experience in molecular imaging and RPT dose modelling research, or 3 years of extensive RPT-specific publications (10+).
• Experience with radiopharmaceuticals as therapeutics in oncology and experience with alpha-emitters strongly desired

Skills and Qualification

• Subject Matter Expert in mathematical pharmacokinetic modeling and its application in radiopharmaceutical research and development.
• Technical skills with dosimetry software, coding and simulation/modeling/statistical tools (e.g. 3D-RD-S, MIM, MIRDcalc, OLINDA, Torch, GATE, SIMIND, SAAM II, SimBiology, Python, Matlab, R, SPSS, ITK-snap, 3D slicer, Elastix, etc.)
• Demonstrated ability to communicate clearly and think creatively when problem-solving on multidisciplinary projects.
• Proven track record for coordinating and aligning cross-functional stakeholders to deliver on corporate timeline in a team environment.
• Excellent communications skills and ability to present and discuss imaging and dosimetry topics clearly and concisely, including with scientific experts globally.
• Demonstrated ability to organize, prioritize, and work effectively with minimal supervision in a constantly changing environment.

• Recognized leadership skills, professional ethics, integrity, and ability to maintain confidential information.
• Willingness to travel when needed (10-15%), including conference attendance which may involve evening and weekend work.
• Current knowledge of global dosimetry guidelines and passion for pioneering alpha-emitting radiotherapeutics a plus.

Physical Demands

While performing the duties of this job, the employee is regularly required to sit, reach with hands and arms, and talk or hear. The employee must occasionally lift and/or move up to 50 pounds. Specific vision abilities required by this job include close vision and distance vision.

We hire for skills and capabilities, not just credentials – if this role excites you, but doesn’t perfectly match your resume, we encourage you to apply anyway.

Compensation Overview:

Remote - United States - US: $134,505 - $162,988


The starting pay range(s) listed above is for full-time employees (FTE). You may also be eligible for additional discretionary incentive cash and stock opportunities. We determine starting pay thoughtfully – carefully considering the nature of the role, required skills, work location, schedule and the knowledge and experience you bring. Final compensation is guided by pay equity principles and applicable employment laws. Compensation programs are reviewed on an ongoing basis and may be adjusted over time to reflect evolving market factors, and individual, team or Company performance.

Benefits:

Subject to the terms and conditions of the applicable plans then in effect, you may be eligible to participate in our comprehensive benefit plans – including wellbeing support, retirement and financial protection benefits, and insurance offerings (medical, dental, vision, life and disability).

U.S.-based exempt employees are eligible for Flexible Time Off (FTO), which provides paid time off without a set accrual limit, subject to manager approval, along with 11 paid company holidays each year.

Non-exempt employees, RayzeBio employees, and employees located in Puerto Rico receive 160 hours of paid vacation annually for new hires (subject to manager approval), 11 paid company holidays, and 3 optional holidays.

Depending on eligibility, employees may also have access to additional time-off benefits, including paid sick leave, up to two paid volunteer days per year, summer hours flexibility, and leaves of absence for medical, personal, parental, caregiver, bereavement, or military needs. Eligible employees also enjoy an annual Global Shutdown between Christmas Day and New Year's Day.

U.S.-based job seekers can explore full benefit offerings at https://careers.bms.com/benefits

RayzeBio and Bristol Myers Squibb

RayzeBio was acquired by Bristol Myers Squibb (BMS) in 2024 and is a wholly-owned subsidiary of BMS; however, RayzeBio will continue to operate as a standalone organization.

Supporting People with Disabilities

BMS and RayzeBio are dedicated to ensuring that people with disabilities can excel through a transparent recruitment process, reasonable workplace accommodations/adjustments and ongoing support in their roles. Applicants can request a reasonable workplace accommodation/adjustment prior to accepting a job offer. If you require reasonable accommodations/adjustments in completing this application, or in any part of the recruitment process, direct your inquiries to [email protected]. Visit careers.bms.com/eeo-accessibility to access our complete Equal Employment Opportunity statement.

Candidate Rights

BMS and RayzeBio will consider qualified applicants with arrest and conviction records, pursuant to applicable laws in your area.

For roles based in Los Angeles County only:  If you live in or expect to work from Los Angeles County if hired for this position, please visit this page for important additional information: https://careers.bms.com/california-residents/

Data Protection

We will never request payments, financial information, or social security numbers during our application or recruitment process. Learn more about protecting yourself at https://careers.bms.com/fraud-protection.

Any data processed in connection with role applications will be treated in accordance with applicable data privacy policies and regulations.

If this posting is missing required information required by local law or incorrect, contact BMS at [email protected] with the Job Title and Requisition number. Do not send application-related inquiries to this email. To check your application status, please login to your Candidate Home Account.

R1606646 : Principal Scientist, Medical Physicist