Principal Software Architect
Company websiteeclinicalsol.com (eClinical Solutions, opens in new tab)
Base salary $168K to $210K
Employer-published annual base salary, USD. Advertised base range in Mansfield, MA
You apply on the employer's own site. Six Figure Work does not handle applications.
- LocationMansfield, MA
- WorkplaceWorkplace not stated
- Status at last checkSource accepting applications when checked
- Last checked (3 h ago) · observed since
About this job
About eClinical Solutions
eClinical Solutions is transforming clinical development with elluminate®, our Clinical Data Cloud, helping life sciences organizations unify, analyze, and unlock the value of their data faster than ever before. By combining a modern cloud platform with expert data services, we empower smarter decisions across the clinical trial lifecycle—accelerating innovation that ultimately improves patient outcomes.
Our engineering teams build enterprise-grade, revenue-generating products at the intersection of cloud, data, analytics, and emerging AI technologies. If you’re excited about building sophisticated software that makes a real-world impact on healthcare, this is the place to do it.
You will make an impact:
The Principal Software Architect will lead the design and evolution of AI-enabled software platforms, helping translate business and product needs into scalable, secure, and responsible technical solutions. This role partners closely with software engineers, product teams, data specialists, and business stakeholders to identify opportunities for AI, guide architecture decisions, review implementations, and mentor teams on modern engineering practices, AI-assisted development, and sound design principles.
Your day to day:
- Research emerging AI, machine learning, generative AI, cloud, and software architecture technologies and evaluate their fit for the product platform
- Analyze existing features, data flows, and system designs for scalability, performance, security, and AI-readiness in order to design and recommend solutions
- Document current and future architectural patterns, including AI integration patterns, model lifecycle considerations, data governance, observability, and responsible AI guardrails
- Communicate complex AI, data, and architecture concepts clearly to technical and cross-functional colleagues
- Define reference architectures for AI-enabled capabilities, including data ingestion, retrieval-augmented generation, model integration, inference services, monitoring, and human-in-the-loop workflows
- Promote responsible AI practices, including privacy, security, explainability, bias mitigation, regulatory awareness, and appropriate use of enterprise data
- Guide teams in the effective use of AI-assisted engineering tools to improve productivity, code quality, documentation, testing, and delivery velocity
AI & Modern Engineering Focus
We’re actively incorporating AI-powered capabilities into our platform, and you’ll help shape how this is done responsibly and effectively in an enterprise environment. This includes:
- Integrating LLMs and AI services into .NET- and Python-based systems
- Designing and implementing AI-assisted workflows, copilots, or intelligent automation features
- Working with agentic AI patterns (e.g., task orchestration, tool-using agents, workflow automation)
- Applying prompt engineering, evaluation techniques, and guardrails to ensure reliability and compliance
- Collaborating with data and platform teams to operationalize AI—not just prototype it
Deep ML expertise is not required—we’re looking for strong engineers who understand how to apply AI capabilities in real products.
Take the first step toward your dream career. Here is what we are looking for in this role.
Qualifications
- 10+ years in web application development, service-oriented architecture, cloud-native platforms, and AI-enabled application design preferred
- 10+ years in full-stack enterprise application development roles, with experience integrating AI, automation, analytics, or data-driven capabilities preferred
- 10+ years leading Software Engineering teams, including mentoring architects and engineers on AI adoption, architectural trade-offs, and modern delivery practices preferred
Professional Skills
- Demonstrate ability to evaluate new technologies, including AI platforms and frameworks, and present comparative analysis of benefits, risks, costs, and implementation considerations
- Strong problem-solving abilities
- Excellent written and verbal communication skills
- Ability to influence technical strategy across product, engineering, security, data, and business stakeholders while advocating for responsible and practical AI adoption
Technical Skills
- Mastery level of software architecture and design, with strong understanding of AI-enabled system design patterns
- Deep understanding of Microsoft .NET and modern application integration patterns for AI-enabled services
- Expert level in relational and non-relational database design, data modeling, and data architecture for analytics and AI use cases
- Experience with enterprise applications in a SaaS Cloud Environment (AWS, Azure, etc.), including scalable deployment patterns for AI, ML, and data-intensive workloads
- Knowledge of AWS products and deployment, with familiarity in cloud AI services, model hosting, automation, monitoring, and secure integration patterns
- Familiarity with AI/ML concepts such as model lifecycle management, prompt engineering, retrieval-augmented generation, evaluation frameworks, observability, and MLOps practices
- Understanding of responsible AI, enterprise data protection, privacy, security, compliance, and governance considerations for production AI systems
AI Use Statement
Employees are expected to appropriately leverage company-approved AI tools to improve productivity and quality while adhering to company policies, protecting confidential information, validating AI-generated content, and exercising sound professional judgment. AI is intended to augment—not replace—professional judgment, critical thinking, accountability, and decision-making. Accountability for all work remains with the employee.
Accelerate your skills and career within a fast-growing company while impacting the future of healthcare. We have shared our story, now we look forward to learning yours!
eClinical is a winner of the 2025 Top Workplaces USA Award for Remote Work! We have also received numerous Top Workplaces Culture Excellence Awards celebrating our exceptional company vision, values, and work-life balance. See all the details here: https://topworkplaces.com/company/eclinical-solutions/
eClinical Solutions is a people first organization. Our inclusive culture values the contribution that diversity brings to our business. We celebrate individual experiences that connect us and that inspire innovation in our community. Our team seeks out opportunities to learn, grow and continuously improve. Bring your authentic self, you are welcome here!
We are proud to be an equal opportunity employer that values diversity. Our management team is committed to the principle that employment decisions are based on qualifications, merit, culture fit and business need.
#LI-AB1
Pay Range
US Pay Ranges
$168,000—$210,000 USD
Source: eClinical Solutions on Greenhouse · View original posting (opens in new tab)
How this pay compares
Base floor $168,000, above 65% of the 529 Software Engineering roles in Massachusetts on this site. The employer's range is $42,000 wide, 25% of the floor. Observed open for 15 days so far (since Oct 24, 2026).
Pay in context
Among 529 Software Engineering roles in Massachusetts listed on this site, the median base floor is $149,000 and the middle half runs from $130,000 to $172,000. This role's floor ($168,000) is above 65% of them; 1 other lists the same floor.
Base floors of 529 Software Engineering roles in Massachusetts
Table
| Floor band | Share | Postings |
|---|---|---|
| $100K to $125K | 20.6% | 109 |
| $125K to $150K | 30.1% | 159 |
| $150K to $175K | 26.1% | 138 |
| $175K to $200K | 14.7% | 78 |
| $200K to $225K | 6.6% | 35 |
| $225K to $250K | 1.5% | 8 |
| $250K to $275K | 0.2% | 1 |
| $275K and up | 0.2% | 1 |
How this is calculated
- Statistic
- Base floor distribution of the cohort
- Formula
- count of cohort postings in each $25K band of published base floor / postings in the cohort
- Denominator
- 529 open postings with this job family in Massachusetts
- Sample size
- 529
- Hidden when
- needs at least 30 postings in the cohort
- Calculation version
- jobpage-analysis-v1
- Data as of
- 2026-11-08
- Employer set
- Open jobs on this site that publish a base salary of $100,000 or more
Only jobs on this site count, and each one publishes a base salary of $100,000 or more, so this compares six-figure jobs with each other, not with the whole market. Computed Nov 8, 2026.
State against nationwide
Median base floor in Massachusetts vs nationwide
Table
| Value | postings | |
|---|---|---|
| Software Engineering, Massachusetts | $149K | 529 |
| Software Engineering, all states | $160K | 12,917 |
| This job's base floor (marked) | $168K |
How this is calculated
- Statistic
- Median floor, state vs nationwide
- Formula
- median published base floor of each cohort
- Denominator
- open postings of this job family
- Sample size
- 529 in Massachusetts; 12917 nationwide
- Hidden when
- needs at least 30 postings in both cohorts
- Calculation version
- jobpage-analysis-v1
- Data as of
- 2026-11-08
- Employer set
- Open jobs on this site that publish a base salary of $100,000 or more
How eClinical Solutions pays
This is the highest base floor among eClinical Solutions's 6 live roles on this site. Across them the median floor is $151,000; the middle half runs from $136,500 to $158,000.
Base floors of eClinical Solutions's 6 live roles
Table
| Floor band | Share | Roles |
|---|---|---|
| $100K to $125K | 16.7% | 1 |
| $125K to $150K | 16.7% | 1 |
| $150K to $175K | 66.7% | 4 |
How this is calculated
- Statistic
- Employer base floor distribution
- Formula
- count of the employer's open roles in each $25K band of published base floor / its open roles
- Denominator
- 6 open public roles at this employer
- Sample size
- 6
- Hidden when
- needs at least 5 roles
- Calculation version
- jobpage-analysis-v1
- Data as of
- current
- Employer set
- Open jobs on this site that publish a base salary of $100,000 or more
Similar pay elsewhere
Other employers' Software Engineering roles in Massachusetts with the nearest published base floor to $168,000, one per employer.
- Staff Motion Planning Engineer Motional · base floor $168,000
- Sr Robotics Software Engineer, Amazon Robotics Amazon · base floor $168,100
- Sr. Software Development Engineer, AWS Transform AWS · base floor $168,100
- Principal Research Architect Bose · base floor $168,300
- Staff Software Engineer Axon · base floor $168,750
This listingPrincipal Software Architect$168K to $210K
Principal AI Engineer – Automation & AI$160K to $200K
Principal Software Engineer$152K to $190K
Principal Software Development Engineer in Test$150K to $175K
Senior Software Engineer$132K to $165K
Senior Clinical Data Manager$110K to $130K
Chart as a table
| Role | Published base |
|---|---|
| Principal Software Architect (this listing) | $168K - $210K |
| Principal AI Engineer – Automation & AI | $160K - $200K |
| Principal Software Engineer | $152K - $190K |
| Principal Software Development Engineer in Test | $150K - $175K |
| Senior Software Engineer | $132K - $165K |
| Senior Clinical Data Manager | $110K - $130K |
Observed changes
No changes to the pay or listing since we first observed this role on Oct 24, 2026 (15 days ago).
- First observed on the employer's board
- Began meeting the published-salary criteria
- Observed since
- Employer-stated posting date
- 2026-08-31
Where this pay comes from
Location as the employer wrote it: Mansfield, MA (Remote)
$168,000—$210,000 USD
- Method
- Employer text, read with fixed rules and re-verified
- Checked
- Rule set
- us-base-v2
The pay passage appears in the employer's own job text. Fixed, deterministic rules located it, and the passage below was checked against the stored copy of the posting.
What we verified
- The pay figures come from the employer's own listing, quoted exactly above.
- The pay is an annual base salary in US dollars with a minimum of at least $100,000.
- The role was publicly listed on the employer's job board when last checked.
We do not verify what the employer will actually offer, whether the employer is still recruiting for the role, or anything beyond what the employer published. Full methodology.