Six Figure Work

Senior Director, Portfolio & Program Management

Vertex Pharmaceuticals

Company websitevrtx.com (Vertex Pharmaceuticals, opens in new tab)

Base salary $242,200  to $363,200

Employer-published annual base salary, USD. Advertised base range in Boston, MA

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  • LocationBoston, MA
  • WorkplaceWorkplace not stated
  • Status at last checkSource accepting applications when checked
  • Last checked (1 h ago) · observed since

About this job

Job Description

General Summary:

The Senior Director, Portfolio & Program Management is a global role within the Program and Portfolio Management (PPM) organization. The incumbent is responsible for championing cross-functional project management excellence to programs across the drug development lifecycle (Research, Pre-clinical and Clinical Development, Registration and Commercialization). The incumbent is expected to lead the application of project management to identify opportunities, shape objectives and drive execution of global strategy for cross-functional drug development teams and portfolio operations initiatives. This role is a key leadership position within PPM, with accountability for the performance and end results of a department/area.

Key Duties and Responsibilities:

  • Provide strategic and operational project leadership to one or more cross-functional teams, directing activities at all stages of the project lifecycle (initiation through closeout)
  • Drive communication cross-functionally and with senior leaders on integrated program planning topics including timelines, status, risks and issues
  • Proactively identify roadblocks and/or constraints impacting strategic imperatives or project execution and lead the team through scenario planning activities
  • Partner with governance forums, senior leaders and/or team lead(s) to align strategy, goals and milestones with corporate objectives
  • Propose innovative approaches, define process improvements and advise leaders on opportunities to optimize project results
  • Determine approach and stakeholders for cross-functional decision-making and issue resolution
  • Oversee completion of project team deliverables and contribute to content development, when appropriate
  • Establish project team operating norms and measure performance
  • Apply subject matter expertise to mentor subordinate managers and high level professionals
  • As a people manager within the organization, may have financial accountabilities and human resource responsibilities for assigned high level professionals and subordinate managers
  • Knowledge and Skills:

  • Broad and comprehensive understanding of project and portfolio management principles, options analysis, strategic planning, business case generation, finance and resource management
  • Leadership experience managing cross-functional teams with an ability to influence teams to prioritize activities and allocate resources to contribute to the development of operational strategy
  • Excellent written and oral communication skills, including well-developed presentation skills
  • Pharmaceutical drug discovery and development expertise across multiple disciplines
  • Organizational skills, an ability to manage multiple priorities
  • Strong collaboration skills to effectively interact with internal or external stakeholders at all levels in the organization
  • Advanced business management knowledge to assess the impact of project decisions on financial and corporate objectives
  • Education and Experience:

  • Typically requires a Bachelor’s degree in Life Sciences or a relevant field
  • Typically requires 12 years of experience and 5 years of management experience, or the equivalent combination of education and experience

  • At Vertex, we embrace continuous learning and encourage employees to stay informed on advances in AI, technology, automation, and industry trends. We seek talent who bring an external perspective, demonstrate curiosity and sound judgment, and thoughtfully adopt new capabilities that improve decision-making, drive innovation, increase efficiency, and help deliver better outcomes for patients.

    Pay Range:

    $242,200 - $363,200

    Disclosure Statement:

    The range provided is based on what we believe is a reasonable estimate for the base salary pay range for this job at the time of posting. This role is eligible for an annual bonus and annual equity awards. Some roles may also be eligible for overtime pay, in accordance with federal and state requirements. Actual base salary pay will be based on a number of factors, including skills, competencies, experience, and other job-related factors permitted by law.

    At Vertex, our Total Rewards offerings also include inclusive market-leading benefits to meet our employees wherever they are in their career, financial, family and wellbeing journey while providing flexibility and resources to support their growth and aspirations.  From medical, dental and vision benefits to generous paid time off (including a week-long company shutdown in the Summer and the Winter), educational assistance programs including student loan repayment, a generous commuting subsidy, matching charitable donations, 401(k) and so much more.

    Flex Designation:

    Hybrid-Eligible Or On-Site Eligible

    Flex Eligibility Status:

    In this Hybrid-Eligible role, you can choose to be designated as: 
    1.    Hybrid: work remotely up to two days per week; or select
    2.    On-Site: work five days per week on-site with ad hoc flexibility.

    Note: The Flex status for this position is subject to Vertex’s Policy on Flex @ Vertex Program and may be changed at any time. 

    #LI-Hybrid
     

    Company Information

    Vertex is a global biotechnology company that invests in scientific innovation.

    Vertex is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, sex, gender identity or expression, age, religion, national origin, ancestry, ethnicity, disability, veteran status, genetic information, sexual orientation, marital status, or any characteristic protected under applicable law. Vertex is an E-Verify Employer in the United States. Vertex will make reasonable accommodations for qualified individuals with known disabilities, in accordance with applicable law.

    Any applicant requiring an accommodation in connection with the hiring process and/or to perform the essential functions of the position for which the applicant has applied should make a request to the recruiter or hiring manager, or contact Talent Acquisition at [email protected]

    Source: Vertex Pharmaceuticals on Workday · View original posting (opens in new tab)

    This range next to 6 other live Vertex Pharmaceuticals roles with the nearest advertised base floor
    Chart as a table
    This range next to 6 other live Vertex Pharmaceuticals roles with the nearest advertised base floor
    RolePublished base
    Senior Director, Portfolio & Program Management (this listing)$242,200 - $363,200
    Clinical Development Medical Director-Nephrology$240K - $360K
    Clinical Development Medical Director- Pain$240K - $360K
    Medical Director, Endocrinology$240K - $360K
    Senior Director, Global HEOR, Hemoglobinopathies$238,400 - $357,600
    Senior Director, Immunology$237,900 - $356,900
    CMC Product Leader, Senior Director - T1D$237,700 - $356,500

    Same $100K to $400K scale as every card. All Vertex Pharmaceuticals roles · How to read the bar

    Observed changes

    1. First observed on the employer's board
    2. Began meeting the published-salary criteria
    Observed since
    Employer-stated posting date
    2026-11-04
    Where this pay comes from

    Location as the employer wrote it: Boston, MA

    $242,200 - $363,200

    Method
    Employer text, read with fixed rules and re-verified
    Checked
    Rule set
    us-base-v2

    The pay passage appears in the employer's own job text. Fixed, deterministic rules located it, and the passage below was checked against the stored copy of the posting.

    What we verified

    • The pay figures come from the employer's own listing, quoted exactly above.
    • The pay is an annual base salary in US dollars with a minimum of at least $100,000.
    • The role was publicly listed on the employer's job board when last checked.

    We do not verify what the employer will actually offer, whether the employer is still recruiting for the role, or anything beyond what the employer published. Full methodology.