Senior Program Manager, Program Leadership and Management
Company websitedeciphera.com (Deciphera Pharmaceuticals, opens in new tab)
Base salary $143K to $197K
Employer-published annual base salary, USD. Advertised base range in Waltham, MA
You apply on the employer's own site. Six Figure Work does not handle applications.
- LocationWaltham, MA
- WorkplaceHybrid
- Status at last checkSource accepting applications when checked
- Last checked (1 h ago) · observed since
About this job
Company Description
Deciphera, a member of Ono Pharmaceutical Co., Ltd., is a biopharmaceutical company focused on discovering, developing, and commercializing important new medicines and providing hope to people living with cancer, neurologic and autoimmune disease. Deciphera is leveraging its proprietary switch-control kinase inhibitor platform and deep expertise in kinase biology to develop a broad portfolio of innovative medicines. In addition to advancing multiple product candidates from Deciphera’s platform in clinical studies, QINLOCK® (ripretinib) is Deciphera’s switch-control kinase inhibitor approved in many countries including the European Union and the United States for the treatment of adult patients with advanced gastrointestinal stromal tumor (GIST) who have received prior treatment with 3 or more kinase inhibitors, including imatinib. ROMVIMZA® (vimseltinib) is a kinase inhibitor approved in the United States for adult patients with symptomatic tenosynovial giant cell tumor (TGCT) for which surgical resection will potentially cause worsening functional limitation or severe morbidity, and in the European Union for adult patients with TGCT associated with clinically relevant physical function deterioration and in whom surgical options have been exhausted or would induce unacceptable morbidity or disability.
The spirit of collaboration that has brought medications to life continues to guide how we operate, grow, and discover new breakthroughs. We cultivate an inclusive culture that values curiosity, creativity, and shared accountability—empowering individuals to challenge the unknown together.
Deciphera offers competitive compensation, including equity-based compensation, and a comprehensive benefits package that includes medical, dental, vision, 401(k) retirement plan, life insurance and a flexible spending account for either health care and/or dependent care.
Job Description
We are seeking a dynamic Sr. Program Manager, Program Leadership & Management, to provide leadership, strategic direction and program management to our Development and Commercial Program Teams. In partnership with the Program Lead, the Sr Program Manager will drive development and deliver results for programs in early to late phase clinical development and/or lifecycle management programs. The successful candidate should possess and demonstrate a firm understanding of drug development, be comfortable with ambiguity, and have strong communication skills, enabling effective communication within program teams and throughout the organization.
This role is highly cross-functional and will involve collaboration with internal and potentially external partners. In partnership with the Program Lead, the Sr. Program Manager is charged with leading daily program management activities, including the development and execution of the program’s Integrated Development Strategy. He/she/they is expected to have an understanding of the overall program strategy and critical path activities, including risks and potential mitigation plans.
Key Responsibilities:
- Strategic partner to the Program Lead, enabling development and ensuring execution of the Integrated Development Strategy- 50%
- In partnership with the Program Lead, drives the development and execution of strategic, integrated development plans through effective leadership of Program Teams
- Provides clear direction on product development requirements to meet the expectations of external customers and business stakeholders
- Monitors program progress and related KPIs, identifies gaps and risks and makes strategic recommendations
- Supports the execution and continuous re-assessment of development strategy in support of the overarching corporate strategy
- Ensures the effective and consistent operation of high-functioning program teams – 50%
- Facilitates program team meetings to ensure productive and efficient discussion
- Ensures clear and timely communication of program strategy and progress to relevant stakeholders
- Orchestrates the integration of sub-teams to support the effectors of Program Teams
Qualifications
- Bachelor’s with 8+ years of R&D and/or drug development project management experience
- Strong organizational and communication skills
- Knowledge of/exposure to the drug development process
- Knowledge of project management software/tools
- Ability to manage team dynamics and handle multiple projects
Preferred Capabilities
- Experience supporting a clinical trial
- Experience in developing drugs for oncology, neurology and/or orphan diseases
Additional Information
Deciphera is committed to fair and equitable compensation practices. The base salary pay range for this role is $143,000 - $197,000. Actual compensation packages will depend on various factors, including, but not limited to depth of experience, education, skillset, overall performance and/or location.
Deciphera believes in providing a competitive compensation and benefits package to all employees. Our base salary is just one component of Deciphera’s competitive total rewards strategy that also includes annual performance bonus, a long-term incentive plan, full range of benefits and other incentive compensation plans (if applicable)
Benefits:
- Competitive salary and annual bonus.
- Comprehensive benefits package including medical, dental, vision insurance, 401(k) retirement plan with company match, and more.
- Generous parental leave and family planning benefits.
- Outstanding culture and opportunities for personal and professional growth.
EQUAL EMPLOYMENT OPPORTUNITY INFORMATION
Deciphera is committed to equal employment opportunity and values diversity. To ensure that we comply with reporting requirements, we invite you complete the confidential survey at the end of this application. Providing this information is optional. It will not be accessible or used in the hiring process, and has no effect on your opportunity for employment. This information will also be treated confidentially. We are committed to make all hiring decisions and other employment decisions on a non-discriminatory basis.
Source: Deciphera Pharmaceuticals on SmartRecruiters · View original posting (opens in new tab)
Pay in context
This role's base floor ($143,000) is above 61% of the 121 Program & Project Management roles in Massachusetts listed on this site. Their median floor is $130,000; the middle half runs from $117,043 to $148,700.
Only jobs on this site count, and each one publishes a base salary of $100,000 or more, so this compares six-figure jobs with each other, not with the whole market. Computed Nov 6, 2026.
This listingSenior Program Manager, Program Leadership and Management$143K to $197K
Senior Manager, Clinical Supply Chain$141,300 to $194,300
Senior Manager, Clinical Data Management$164K to $200K
Senior Manager, Technical Clinical Data Management$164K to $200K
Associate Director, Sales Operations$170K to $234K
Associate Director, Clinical Science$171K to $236K
Director, Global Medical Writing$175K to $215K
Chart as a table
| Role | Published base |
|---|---|
| Senior Program Manager, Program Leadership and Management (this listing) | $143K - $197K |
| Senior Manager, Clinical Supply Chain | $141,300 - $194,300 |
| Senior Manager, Clinical Data Management | $164K - $200K |
| Senior Manager, Technical Clinical Data Management | $164K - $200K |
| Associate Director, Sales Operations | $170K - $234K |
| Associate Director, Clinical Science | $171K - $236K |
| Director, Global Medical Writing | $175K - $215K |
Observed changes
- Began meeting the published-salary criteria
- First observed on the employer's board
- Observed since
- Employer-stated posting date
- 2026-08-25
Where this pay comes from
Location as the employer wrote it: Waltham, MA, United States
Deciphera is committed to fair and equitable compensation practices. The base salary pay range for this role is $143,000 - $197,000. Actual compensation packages will depend on various factor
- Method
- Employer text, read with fixed rules and re-verified
- Checked
- Rule set
- us-base-v2
The pay passage appears in the employer's own job text. Fixed, deterministic rules located it, and the passage below was checked against the stored copy of the posting.
What we verified
- The pay figures come from the employer's own listing, quoted exactly above.
- The pay is an annual base salary in US dollars with a minimum of at least $100,000.
- The role was publicly listed on the employer's job board when last checked.
We do not verify what the employer will actually offer, whether the employer is still recruiting for the role, or anything beyond what the employer published. Full methodology.
