Principal Scientist
Company websiteroche.com (Roche, opens in new tab)
Base salary $143,200 to $265,900
Employer-published annual base salary, USD. Advertised base range in South San Francisco, CA
You apply on the employer's own site. Six Figure Work does not handle applications.
- LocationSouth San Francisco, CA
- WorkplaceWorkplace not stated
- Status at last checkSource accepting applications when checked
- Last checked (1 h ago) · observed since
About this job
The Opportunity
SE7
As a Principal Scientist in Small Molecule Biomarkers (Metabolomics & Lipidomics) within our Drug Metabolism and Pharmacokinetics (DMPK) team, you will play a key role in advancing safe and effective therapeutics for patients. Joining Genentech Research and Early Development (gRED), you will empower drug discovery across the organization by developing high-throughput mass spectrometry workflows and applying modern tools—including Generative AI—to drive biological insights.
Key Responsibilities:
● Method Development: Design and apply LC-HRMS and LC-MS/MS methods to acquire high-quality mass spectrometry biomarker data supporting drug discovery and development.
● Experimental Execution: Prepare and execute global and targeted metabolomics and lipidomics protocols across diverse biological specimens, including biofluids, tissues, and cells.
● Data & AI Workflows: Perform mass spectrometry data processing and statistical analysis; build or leverage Generative AI tools and software workflows to scale analysis and reporting.
● Quality & Insight: Oversee rigorous bioanalytical quality control using common industry practices and critical analytical reasoning.
● Cross-Functional Collaboration: Partner with multidisciplinary teams and project stakeholders to translate complex omics data into actionable drug target research.
Who You Are
You are an innovative analytical scientist with a passion for cellular metabolism, mass spectrometry technology, and emerging computational tools. You thrive in collaborative, high-impact environments and want to translate cutting-edge omics data into life-changing medicines.
Qualifications & Experience:
● Education & Industry Experience: PhD in biological, chemical, pharmaceutical sciences, or a related field, accompanied by 3–5 years of direct experience in the biotechnology or pharmaceutical industry.
● Bioanalytical Expertise: Proven experience designing and executing assays for endogenous small molecule metabolites or lipids, including sample preparation techniques like precipitation, liquid-liquid, or solid-phase extraction.
● Technical Mastery: Practical experience operating and troubleshooting modern LC-MS platforms (e.g., UHPLC, triple quadrupole, high-resolution mass spectrometers) and using analytical data processing software.
● Metabolic & Computational Insight: Solid foundation in cellular metabolism, coupled with hands-on experience or strong aptitude using Generative AI tools for coding and biological insight generation.
● Collaboration & Communication: Excellent communication skills with a proven track record of working effectively in multidisciplinary project teams.
Relocation benefits are available for this posting.
The expected salary range for this position based on the primary location of California is $143,200 - $265,900. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
Source: Roche on Workday · View original posting (opens in new tab)
This listingPrincipal Scientist$143,200 to $265,900
Principal Scientist - Oligonucleotide Design and ChemistryFrom $143,200
Principal Scientist, Peptide Therapeutics$143,200 to $265,900
Principal Scientist, Lab Head, Immunology, Cell Therapy$143,200 to $265,900
Principal Scientist, Lab Head, Synthetic Immunity$143,200 to $265,900
R&D Business Insight and Digital Solution Lead$143,400 to $266,200
Senior Software Engineer, Research Biology$142,500 to $264,700
Chart as a table
| Role | Published base |
|---|---|
| Principal Scientist (this listing) | $143,200 - $265,900 |
| Principal Scientist - Oligonucleotide Design and Chemistry | From $143,200 |
| Principal Scientist, Peptide Therapeutics | $143,200 - $265,900 |
| Principal Scientist, Lab Head, Immunology, Cell Therapy | $143,200 - $265,900 |
| Principal Scientist, Lab Head, Synthetic Immunity | $143,200 - $265,900 |
| R&D Business Insight and Digital Solution Lead | $143,400 - $266,200 |
| Senior Software Engineer, Research Biology | $142,500 - $264,700 |
Observed changes
- First observed on the employer's board
- Began meeting the published-salary criteria
- Observed since
Where this pay comes from
Location as the employer wrote it: South San Francisco
The expected salary range for this position based on the primary location of California is $143,200 - $265,900. Actual pay will be determined based on experience, qualifi
- Method
- Employer text, read with fixed rules and re-verified
- Checked
- Rule set
- us-base-v2
The pay passage appears in the employer's own job text. Fixed, deterministic rules located it, and the passage below was checked against the stored copy of the posting.
What we verified
- The pay figures come from the employer's own listing, quoted exactly above.
- The pay is an annual base salary in US dollars with a minimum of at least $100,000.
- The role was publicly listed on the employer's job board when last checked.
We do not verify what the employer will actually offer, whether the employer is still recruiting for the role, or anything beyond what the employer published. Full methodology.