Principal Scientist II, Translational Biomarker Strategy Lead
Company websitenovartis.com (Novartis, opens in new tab)
Base salary $114,100 to $211,900
Employer-published annual base salary, USD. Advertised base range in United States
You apply on the employer's own site. Six Figure Work does not handle applications.
- LocationUnited States
- WorkplaceWorkplace not stated
- Status at last checkSource accepting applications when checked
- Last checked (1 h ago) · observed since
About this job
Band
Level 4Job Description Summary
Novartis Biomedical Research is seeking a highly motivated and scientifically accomplished Translational Biomarker Strategy Lead to serve as the biomarker representative and strategic advisor on DAx project teams.This role will lead the development and execution of preclinical and translational biomarker strategies from target validation through development candidate nomination and early clinical planning. The Biomarker Strategy Lead will partner closely with Biology, In Vitro, In Vivo, Data Science and Biomarker Development to ensure biomarker plans are aligned with key program decisions and support target engagement, pharmacodynamic assessment, patient stratification, and translational decision-making.
The successful candidate will act as the single point of contact for biomarker strategy within assigned DAx programs, integrating scientific, technical, operational, and external capabilities to deliver execution-ready biomarker plans that enable efficient progression of the portfolio.
Job Description
Major accountabilities:
- Lead development of stage-appropriate preclinical and translational biomarker strategies for DAx programs from target validation through early clinical development readiness.
- Serve as the biomarker representative and single point of contact on assigned DAx project teams.
- Define biomarker hypotheses, context of use, evidence requirements, and decision criteria aligned with program milestones.
- Develop integrated biomarker plans encompassing assays, models, samples, analyses, timelines, and external partnerships.
- Partner across Biology, In Vitro, In Vivo, Data Science, Preclinical Safety, Quantitative Sciences, Translational Medicine, and Biomarker Development to align biomarker activities and execution.
- Generate translational evidence linking target biology, pharmacology, and biomarkers to support key portfolio decisions.
- Drive external collaborations and leverage innovative technologies, datasets, and human sample resources to strengthen biomarker strategies and research-to-development transition.
Minimum Qualifications
- PhD, MD, PharmD, or equivalent in biology, pharmacology, immunology, translational medicine, molecular biology, or related discipline.
- 7+ years of experience in translational research, biomarker strategy, biomarker discovery, or drug development within the pharmaceutical or biotechnology industry.
- Demonstrated experience developing biomarker strategies supporting drug discovery and development programs.
- Strong understanding of biomarker applications including target engagement, pharmacodynamics, patient stratification, disease activity, and mechanism-based biomarkers.
- Experience leading cross-functional matrix teams and influencing scientific strategy without direct authority.
- Excellent communication, presentation, and stakeholder management skills.
Rewards
At Novartis, we’re committed to reimagining medicine together - and rewarding the people who make it happen.
The rewards of being part of our team go far beyond base pay and incentives. We also offer a variety of competitive benefits in kind to help you thrive personally and professionally, such as insurance plans, retirement plans, wellbeing resources and global recognition programs. In addition, we provide flexible and hybrid working options, where possible, and a minimum of 14 weeks paid parental leave.
Expected Annual Base Salary Range for role:
- USA: 114,100.00 - 211,900.00 USD Annual
The salary offered is determined based on gender-neutral objectives, such as relevant skills, competencies and experience in accordance with the Novartis pay setting policy and upon joining Novartis will be reviewed periodically.
In addition to your base salary, you may be eligible for a performance-based bonus depending on certain performance parameters. Further details will be provided during the application process.
Pay equity is a fundamental principle of our employment policy and reflects our commitment to create a diverse, equitable and inclusive environment that treats all employees with dignity and respect, as outlined in our Code of Ethics.
Read our brochure to learn more about our global total rewards offering: https://www.novartis.com/sites/novartis_com/files/novartis-life-handbook.pdf
Note: Benefits and compensation may vary by country and are subject to local legal requirements, including provisions of collective bargaining agreements where applicable. A full overview of your compensation package, including any relevant collective bargaining agreement details applicable to your role based on your employment location and Novartis employer entity, will be communicated separately to you during the application process.
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Why Novartis: Helping people with disease and their families takes more than innovative science. It takes a community of smart, passionate people like you. Collaborating, supporting and inspiring each other. Combining to achieve breakthroughs that change patients’ lives. Ready to create a brighter future together? https://www.novartis.com/about/strategy/people-and-culture
Benefits and Rewards: Read our handbook to learn about all the ways we’ll help you thrive personally and professionally: https://www.novartis.com/careers/benefits-rewards
EEO Statement:
The Novartis Group of Companies are Equal Opportunity Employers. We do not discriminate in recruitment, hiring, training, promotion or other employment practices for reasons of race, color, religion, gender, national origin, age, sexual orientation, gender identity or expression, marital or veteran status, disability, or any other legally protected status. We strive to create an inclusive workplace that cultivates bold innovation through collaboration and empowers our people to unleash their full potential.
Accessibility and reasonable accommodations
The Novartis Group of Companies are committed to working with and providing reasonable accommodation to individuals with disabilities. If, because of a medical condition or disability, you need a reasonable accommodation for any part of the application process, or in order to perform the essential functions of a position, please send an e-mail to [email protected] call +1 (877)395-2339 and let us know the nature of your request and your contact information. Please include the job requisition number in your message.
https://www.novartis.com/careers/careers-research/notice-all-applicants-us-job-openings
Salary Range
$114,100.00 - $211,900.00Skills Desired
Analytical Thinking, Chemical Biology, Chemistry, Clinical Trials, Collaboration, Curious Mindset, Data Analysis, Detail-Oriented, Drug Development, Ethics, Gene Therapy, Immunology, Inventory Management, Machine Learning (ML), Medical Research, Molecular Biology, Python (Programming Language), ScienceSource: Novartis on Workday · View original posting (opens in new tab)
Pay in context
This role's base floor ($114,100) is above 13% of the 310 Science & Research roles in Massachusetts listed on this site; 1 other lists the same floor. Their median floor is $159,500; the middle half runs from $129,730 to $190,600.
Only jobs on this site count, and each one publishes a base salary of $100,000 or more, so this compares six-figure jobs with each other, not with the whole market. Computed Nov 8, 2026.
This listingPrincipal Scientist II, Translational Biomarker Strategy Lead$114,100 to $211,900
Maintenance Lead$114,100 to $211,900
Site HSE Manager$114,100 to $211,900
Site Engineering Manager, Manufacturing (Isotopes)$114,100 to $211,900
Sr. Engineer, MS&T – Aseptic Drug Product$114,100 to $211,900
Sr. Manager, Automation – GTx Lead$114,100 to $211,900
Sr. Engineer, MS&T – Aseptic Drug Product$114,100 to $211,900
Chart as a table
| Role | Published base |
|---|---|
| Principal Scientist II, Translational Biomarker Strategy Lead (this listing) | $114,100 - $211,900 |
| Maintenance Lead | $114,100 - $211,900 |
| Site HSE Manager | $114,100 - $211,900 |
| Site Engineering Manager, Manufacturing (Isotopes) | $114,100 - $211,900 |
| Sr. Engineer, MS&T – Aseptic Drug Product | $114,100 - $211,900 |
| Sr. Manager, Automation – GTx Lead | $114,100 - $211,900 |
| Sr. Engineer, MS&T – Aseptic Drug Product | $114,100 - $211,900 |
Observed changes
- First observed on the employer's board
- Began meeting the published-salary criteria
- Observed since
- Employer-stated posting date
- 2026-08-05
Where this pay comes from
Location as the employer wrote it: Cambridge (USA)
$114,100.00 - $211,900.00
- Method
- Employer text, read with fixed rules and re-verified
- Checked
- Rule set
- us-base-v2
The pay passage appears in the employer's own job text. Fixed, deterministic rules located it, and the passage below was checked against the stored copy of the posting.
What we verified
- The pay figures come from the employer's own listing, quoted exactly above.
- The pay is an annual base salary in US dollars with a minimum of at least $100,000.
- The role was publicly listed on the employer's job board when last checked.
We do not verify what the employer will actually offer, whether the employer is still recruiting for the role, or anything beyond what the employer published. Full methodology.