Senior Research Associate, DMPK

Revolution Medicines is a global, commercial-state oncology company dedicated to discovering, developing and delivering innovative medicines for patients with RAS-addicted cancers. Leveraging its differentiated RAS(ON) tri-complex inhibitor platform, the company is advancing a broad, integrated portfolio of oral RAS(ON) inhibitors designed to directly target the active, cancer-driving state of RAS. Founded on rigorous scientific inquiry and a willingness to challenge long-held assumptions, Revolution Medicines is committed to changing the trajectory of disease for patients with RAS-addicted cancers worldwide.

Our people are united by a shared way of working: follow the science, challenge assumptions, act with urgency and hold ourselves to a high standard of rigor—all in service of patients.

The Opportunity:

As a key member of our dynamic DMPK lab team within DMPK under the non-clinical development and clinical pharmacology (NDCP) department, you will have responsibilities including, but not limited to:

• Develop LC-MS/MS methods and analyze in vivo and in vitro samples to support ADME, pharmacokinetic, efficacy, and toxicokinetic studies, etc.

• Handle a variety of tissues, including tumors, from tissue homogenization through sample preparation for bioanalysis.

• Perform data analysis, prepare experimental result reports, and upload data to electronic notebooks.

• Conduct in vitro ADME/DMPK assays in biological matrices, including hepatocytes, microsomes, blood, and plasma, ect.

• Support laboratory operations, including lab safety, LC-MS/MS instrument maintenance and troubleshooting.

Required Skills, Experience and Education:

• Bachelor’s or master’s degree in pharmaceutical sciences or a related scientific discipline, with 5+ years of industry experience for bachelor’s degree holders or 3+ years for master’s degree holders.

• Hands-on experience in operating and maintaining LC-MS/MS systems.

• Hands-on experience in LC-MS/MS method development and bioanalytical analysis.

• Knowledge of biological sample preparation and extraction techniques for downstream LC-MS/MS analysis.

• Hands-on experience in HPLC/UPLC method development.

• Ability to customize and follow established assay protocols.

• Ability to manage multiple laboratory and project tasks efficiently.

• Ability to work effectively in a flexible, team-oriented environment.

• Highly organized and detail-oriented, with excellent recordkeeping skills and the ability to adapt to a dynamic, fast-paced environment.

Preferred Skills:

• Previous hands-on experience in SCIEX QTRAP mass spectrometers.

• Previous hands-on experiences on bioanalytical method development in compliance with regulatory requirements.

• Working experience in DMPK lab.

#LI-CT1 #LI-ONSITE

The base pay salary range for this full-time position for candidates working onsite at our headquarters in Redwood City, CA is listed below. The range displayed on each job posting is intended to be the base pay salary range for an individual working onsite in Redwood City and will be adjusted for the local market a candidate is based in. Our base pay salary ranges are determined by role, level, and location. Individual base pay salary is determined by multiple factors, including job-related skills, experience, market dynamics, and relevant education or training.

Please note that base pay salary range is one part of the overall total rewards program at RevMed, which includes competitive cash compensation, robust equity awards, strong benefits, and significant learning and development opportunities.

Revolution Medicines is an equal opportunity employer and prohibits unlawful discrimination based on race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, disability, marital status, medical condition, and veteran status.

Revolution Medicines takes protection and security of personal data very seriously and respects your right to privacy while using our website and when contacting us by email or phone. We will only collect, process and use any personal data that you provide to us in accordance with our CCPA Notice and Privacy Policy. For additional information, please contact [email protected].

Base Pay Salary Range

$106,000—$126,000 USD

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