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Senior Staff / Principal Software Engineer, Rust Genomics Infrastructure

St. Jude Children's Research Hospital

Company websitestjude.org (St. Jude Children's Research Hospital, opens in new tab)

Base salary $125,840  to $238,160

Employer-published annual base salary, USD. Advertised base range in Memphis, TN

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  • LocationMemphis, TN
  • WorkplaceWorkplace not stated
  • Status at last checkSource accepting applications when checked
  • Last checked (29 min ago) · observed since

About this job

The Senior Staff Software Engineer manages assigned software systems through strategic direction, technical design, implementation, and operational health.

The Principal Software Engineer anticipates, identifies, and provides solutions for complex problems through deep technical analysis.

St. Jude is seeking a seasoned Rust developer to lead the development of software to facilitate genomics analysis at scale. Foundationally, this position will work on writing (or rewriting) tools that underpin the genomics ecosystem in Rust. This position requires a deep understanding of the Rust programming language and agility working with the core concepts therein, proficiency in algorithm development with a focus on optimization via profiling, and a track record of developing software with strong documentation and testing. A portion of this position’s time will be dedicated to open-source software development: for these projects, active community management and engagement are vital to ensuring adoption of these tools. Beyond engineering, both synchronous and asynchronous communication skills—particularly in the areas of ideating on project direction, tracking project progress, and overall engagement with the community of these tools—are critical to ensuring success of the project. Of note, specific experience with bioinformatics and genomics is not required; we’re targeting talented software engineers who want to expand into the fields of bioinformatics and genomics (visit https://learngenomics.dev/ to learn more about genomics in the context of software engineering).

Senior Staff Software Engineer

Job Responsibilities:

  • Independently manage software systems within an area of responsibility, providing strategic direction, technical design, implementation, and operational health, coordinating efforts with other staff as necessary

  • Serve as a technology advocate and technical thought leader within the assigned area, inspiring productive change through technology solutions, guiding application strategy, and providing recommendations for future development

  • Architect, design, and develop “best-in-class” solutions to all but the most complex problems in the scientific domain

  • Use scientific domain knowledge to perform data analysis and identify problems and areas for improvement and generate strategic leads

  • Stay educated on existing and state-of-the-art technologies, and evaluate technology fits for effective delivery

  • Engage with and influence senior leadership and other decision-makers

  • Participate in the preparation of scientific manuscripts and presentations

  • Drive processes for continuous learning and development across teams, mentoring and guiding when required to ensure quality and productivity

  • Perform other duties as assigned to meet the goals and objectives of the department and institution.

  • Maintains regular and predictable attendance.

Minimum Education and/or Training:

  • Bachelor's degree in computer science, data science, information science, business, or related field.

  • Master's degree preferred.

Minimum Experience:

  • Minimum Requirement: Bachelor's degree with 8+ years of experience in computer science, data science, information science, business, or related field.

  • Experience Exception: Master's degree with 6+ years of experience in computer science, data science, information science, business, or related field.

  • Experience with programming languages, databases, and software development lifecycle.

  • Substantial experience within the technical and/or scientific domain.

  • Proven performance in earlier role/comparable role.

Principal Software Engineer

Job Responsibilities:

  • Anticipate problems and opportunities in the scientific domain; advocate for strategic plans based on deep technical and scientific knowledge
  • Independently perform deep analysis of scientific data to identify problems and opportunities for improvement.
  • Mentor junior staff in technical and scientific concepts and actively contribute to local body of knowledge.
  • As part of a multi-disciplinary team, identify technical solutions to complex scientific problems and lead the implementation of those solutions.
  • Serve as a technology advocate and technical thought leader within the assigned area, inspiring productive change through technology solutions, guiding application strategy, and providing recommendations for future development.
  • Prepare scientific manuscripts and presentations.
  • Perform other duties as assigned to meet the goals and objectives of the department and institution.
  • Maintains regular and predictable attendance.

Minimum Education and/or Training:

  • Bachelor's degree in computer science, data science, information science, business, or related field required.
  • Master's degree preferred.

Minimum Experience:

  • Minimum Requirement: Bachelor's degree with 12+ years of relevant experience.
  • Experience Exception: Master's degree with 10+ years of relevant experience.
  • Experience with programming languages, databases, and software development lifecycle.
  • Significant experience within the technical and/or scientific domain required.
  • Proven leadership in earlier role/comparable role.

Compensation

In recognition of certain U.S. state and municipal pay transparency laws, St. Jude is including a reasonable estimate of the compensation range for this role. This is an estimate offered in good faith and a specific salary offer takes into account factors that are considered in making compensation decisions including but not limited to skill sets, experience and training, licensure and certifications, and other business and organizational needs. It is not typical for an individual to be hired at or near the top of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $125,840 - $238,160 per year for the role of Senior Staff / Principal Software Engineer, Rust Genomics Infrastructure.

Explore our exceptional benefits!

St. Jude is an Equal Opportunity Employer

No Search Firms

St. Jude Children's Research Hospital does not accept unsolicited assistance from search firms for employment opportunities. Please do not call or email. All resumes submitted by search firms to any employee or other representative at St. Jude via email, the internet or in any form and/or method without a valid written search agreement in place and approved by HR will result in no fee being paid in the event the candidate is hired by St. Jude.

Source: St. Jude Children's Research Hospital on Workday · View original posting (opens in new tab)

Pay in context

This role's base floor ($125,840) is above 16% of the 10,388 Software Engineering roles nationwide listed on this site; 1 other lists the same floor. Their median floor is $160,000; the middle half runs from $140,000 to $191,000.

Only jobs on this site count, and each one publishes a base salary of $100,000 or more, so this compares six-figure jobs with each other, not with the whole market. Computed Nov 7, 2026.

This range next to 6 other live St. Jude Children's Research Hospital roles with the nearest advertised base floor
Chart as a table
This range next to 6 other live St. Jude Children's Research Hospital roles with the nearest advertised base floor
RolePublished base
Senior Staff / Principal Software Engineer, Rust Genomics Infrastructure (this listing)$125,840 - $238,160
Director of Scientific Research, Single-molecule Imaging Center$125,840 - $238,160
Senior Manager of Research Storage & Data Infrastructure$125,840 - $238,160
Dir-Environmental Health & Safety$125,840 - $238,160
Data Scientist - Clinical Machine Learning & Flow Cytometry$125,840 - $238,160
Imaging Sciences Fabrication and Design Core Director$125,840 - $238,160
Director of the Hartwell Center for Biotechnology Shared Resource$125,840 - $238,160

Same $100K to $400K scale as every card. All St. Jude Children's Research Hospital roles · How to read the bar

Observed changes

  1. First observed on the employer's board
  2. Began meeting the published-salary criteria
Observed since
Employer-stated posting date
2026-06-08
Where this pay comes from

Location as the employer wrote it: Memphis, TN

of the salary range and compensation decisions are dependent on the facts and circumstances of each case. A reasonable estimate of the current salary range is $125,840 - $238,160 per year for the role of Senior Staff / Principal Software

Method
Employer text, read with fixed rules and re-verified
Checked
Rule set
us-base-v2

The pay passage appears in the employer's own job text. Fixed, deterministic rules located it, and the passage below was checked against the stored copy of the posting.

What we verified

  • The pay figures come from the employer's own listing, quoted exactly above.
  • The pay is an annual base salary in US dollars with a minimum of at least $100,000.
  • The role was publicly listed on the employer's job board when last checked.

We do not verify what the employer will actually offer, whether the employer is still recruiting for the role, or anything beyond what the employer published. Full methodology.