Principal/Senior Scientist, Translational Biomarkers
Company websitenewlimit.com (NewLimit, opens in new tab)
Base salary $155K to $200K
Employer-published annual base salary, USD. Advertised base range in South San Francisco, CA
You apply on the employer's own site. Six Figure Work does not handle applications.
- LocationSouth San Francisco, CA
- WorkplaceWorkplace not stated
- Status at last checkSource accepting applications when checked
- Last checked (1 h ago) · observed since
About this job
About NewLimit
NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.
This Position
NewLimit is seeking a Senior/Principal Scientist with deep expertise in molecular biology and translational biomarker assay development. In this role, you will lead the discovery, development, and qualification of pharmacodynamic (PD) biomarker assays that characterize the biological activity of our mRNA-LNP medicines in preclinical and IND-enabling studies. You will serve as a technical leader within our bioanalytical function, shaping PD biomarker strategy from discovery through fit-for-purpose qualification to advance our therapeutic programs toward clinical milestones.
What you’ll do
- Discover pharmacodynamic biomarkers to support the clinical development of drugs across multiple programs
- Own the design, development, and qualification of PD biomarker assays across various platforms to support preclinical studies
- Define go/no-go criteria for biomarker advancement and contribute to the PD biomarker strategy in regulatory submissions
- Drive data analysis, interpretation, and reporting for bioanalytical studies
- Contribute to sample processing workflows including tissue harvesting, primary cell culture, and complex matrix handling
- Mentor research associates, establish SOPs, and build institutional knowledge within the bioanalytical function
Requirements
- PhD in molecular biology, biochemistry, cell biology, or a related field or equivalent industry experience (5+ years)
- 3+ years of hands-on experience in various quantitative bioanalytical assay platforms (e.g., RT-qPCR, ddPCR, ELISA, MSD, Olink, SOMAscan, NGS-based methods) in complex biological matrices (serum, plasma, tissue homogenates)
- Strong working knowledge of bioanalytical method qualification/validation principles for PD biomarker measurements, including familiarity with ICH M10 guidelines and fit-for-purpose frameworks
- History of delivering results for bioanalytical projects -- you've discovered a PD biomarker or built an assay and solved all the problems along the way
- Experience with primary cell culture and tissue-derived sample workflows
Nice to have
- Experience in bioanalytical method transfer and CRO management for outsourced discovery or assay qualification work
- Familiarity with preclinical drug development timelines and regulatory submissions (IND, TGA, CTD format)
- Experience in LNP-RNA biodistribution and PD assay development
- Experience developing products in emerging therapeutic modalities (gene therapy, nucleic acid therapies, cell therapy)
Benefits
NewLimit provides generous benefits so our team can remain focused on our mission:
- Comprehensive Health, Dental, and Vision insurance
- 401(k) plan with company match
- Paid parental leave
- Industry-leading PTO: 20 days per year plus holidays
- On-site meals and snacks
Salary Range: $155,000 to $200,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO. Learn more at: https://www.newlimit.com/careers *This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future.
Source: NewLimit on Greenhouse · View original posting (opens in new tab)
Pay in context
This role's base floor ($155,000) is above 46% of the 492 Science & Research roles in California listed on this site; 1 other lists the same floor. Their median floor is $158,777; the middle half runs from $126,066 to $200,000.
Only jobs on this site count, and each one publishes a base salary of $100,000 or more, so this compares six-figure jobs with each other, not with the whole market. Computed Nov 8, 2026.
This listingPrincipal/Senior Scientist, Translational Biomarkers$155K to $200K
Lead Security & Infrastructure Engineer$160K to $220K
Principal/Senior Scientist, mRNA Engineering$170K to $200K
Senior Manager, Lab Operations$140K to $170K
Scientist/Senior Scientist, Immunology$130K to $180K
Scientist- Delivery Sciences-targeted LNPs (tLNPs)$130K to $171K
Scientist, Metabolism$130K to $165K
Chart as a table
| Role | Published base |
|---|---|
| Principal/Senior Scientist, Translational Biomarkers (this listing) | $155K - $200K |
| Lead Security & Infrastructure Engineer | $160K - $220K |
| Principal/Senior Scientist, mRNA Engineering | $170K - $200K |
| Senior Manager, Lab Operations | $140K - $170K |
| Scientist/Senior Scientist, Immunology | $130K - $180K |
| Scientist- Delivery Sciences-targeted LNPs (tLNPs) | $130K - $171K |
| Scientist, Metabolism | $130K - $165K |
Observed changes
- First observed on the employer's board
- Began meeting the published-salary criteria
- Observed since
- Employer-stated posting date
- 2026-04-17
Where this pay comes from
Location as the employer wrote it: South San Francisco
Salary Range: $155,000 to $200,000. Compensation for the role will depend on a number of facto
- Method
- Employer text, read with fixed rules and re-verified
- Checked
- Rule set
- us-base-v2
The pay passage appears in the employer's own job text. Fixed, deterministic rules located it, and the passage below was checked against the stored copy of the posting.
What we verified
- The pay figures come from the employer's own listing, quoted exactly above.
- The pay is an annual base salary in US dollars with a minimum of at least $100,000.
- The role was publicly listed on the employer's job board when last checked.
We do not verify what the employer will actually offer, whether the employer is still recruiting for the role, or anything beyond what the employer published. Full methodology.