Senior Scientist / Scientist, In Vivo Pharmacology
Company websitenewlimit.com (NewLimit, opens in new tab)
Base salary $130K to $180K
Employer-published annual base salary, USD. Advertised base range in South San Francisco, CA
You apply on the employer's own site. Six Figure Work does not handle applications.
- LocationSouth San Francisco, CA
- WorkplaceWorkplace not stated
- Status at last checkSource accepting applications when checked
- Last checked (2 h ago) · observed since
About this job
Company info
NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.
Description
NewLimit is seeking a talented Scientist / Senior Scientist of In Vivo Pharmacology to join our Translational Sciences team. This critical role designs and executes in vivo studies to evaluate pioneering epigenetic reprogramming therapeutics across our entire portfolio. As a subject matter expert in nonclinical and PK/PD study design, you will lead in vivo pharmacology strategies, collaborate cross-functionally with therapeutic area teams, and directly drive therapeutic candidate selection.
As a Senior Scientist/Scientist on our team, you will:
- Design, execute, and interpret in vivo pharmacology studies (PK/PD, efficacy, dose-response) across multiple disease models and therapeutic programs
- Collaborate with Epigenetic Editing, Predictive Modeling, and other therapeutic area teams to evaluate epigenetic reprogramming payloads in relevant animal models
- Develop and refine animal models of aging and age-related disease to support translational studies
- Oversee study design, protocol development, and CRO/vendor relationships for in vivo studies
- Analyze and interpret in vivo data (PK/PD, biomarkers, functional endpoints) to drive pre-clinical decision making
- Contribute to regulatory-enabling study design and documentation as programs progress toward clinical
Requirements
- Ph.D. in pharmacology, physiology, biology or a related field or equivalent industry experience (5+ years for Scientist; 8+ years for Senior Scientist)
- Demonstrated experience designing and executing in vivo pharmacology studies (PK, PD, efficacy, dose-range finding) in rodent models
- Experience with study design, dosing regimens, and route-of-administration selection
- Experience analyzing and interpreting in vivo pharmacology data to inform program decisions
- Experience leading project workflows and providing technical mentorship to junior laboratory staff
- History of contributing to a drug development program at the pre-clinical or clinical development stage
Nice to have
- Experience with liver biology, hepatic disease models, or hepatocyte-directed delivery
- Experience with nucleic acid or viral vector delivery in vivo
- Experience with GLP-enabling or IND-enabling study design
- Experience with single cell genomics or pooled screening approaches applied to in vivo readouts
Benefits
NewLimit offers generous benefits to ensure our team can focus on our mission:
- Health, dental, and vision insurance
- 401(k) with company match
- Paid parental leave
- Industry-leading paid time off (PTO) — 20 days/year for all employees + holidays
- Meals and snacks on-site
Salary Range: $130,000 to $180,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. NewLimit offers a competitive benefits package, which includes a 401k, healthcare coverage, and 20 days of PTO. Learn more at: https://www.newlimit.com/careers *This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future.
Source: NewLimit on Greenhouse · View original posting (opens in new tab)
Pay in context
This role's base floor ($130,000) is above 28% of the 492 Science & Research roles in California listed on this site; 5 others list the same floor. Their median floor is $158,777; the middle half runs from $126,066 to $200,000.
Only jobs on this site count, and each one publishes a base salary of $100,000 or more, so this compares six-figure jobs with each other, not with the whole market. Computed Nov 8, 2026.
This listingSenior Scientist / Scientist, In Vivo Pharmacology$130K to $180K
Scientist/Senior Scientist, Immunology$130K to $180K
Scientist- Delivery Sciences-targeted LNPs (tLNPs)$130K to $171K
Scientist, Metabolism$130K to $165K
Scientist/Senior Scientist$130K to $180K
Scientist, mRNA Downstream PurificationFrom $120K
Scientist, mRNA Analytical DevelopmentFrom $120K
Chart as a table
| Role | Published base |
|---|---|
| Senior Scientist / Scientist, In Vivo Pharmacology (this listing) | $130K - $180K |
| Scientist/Senior Scientist, Immunology | $130K - $180K |
| Scientist- Delivery Sciences-targeted LNPs (tLNPs) | $130K - $171K |
| Scientist, Metabolism | $130K - $165K |
| Scientist/Senior Scientist | $130K - $180K |
| Scientist, mRNA Downstream Purification | From $120K |
| Scientist, mRNA Analytical Development | From $120K |
Observed changes
- Began meeting the published-salary criteria
- First observed on the employer's board
- Observed since
- Employer-stated posting date
- 2026-09-04
Where this pay comes from
Location as the employer wrote it: South San Francisco
Salary Range: $130,000 to $180,000. Compensation for the role will depend on a number of facto
- Method
- Employer text, read with fixed rules and re-verified
- Checked
- Rule set
- us-base-v2
The pay passage appears in the employer's own job text. Fixed, deterministic rules located it, and the passage below was checked against the stored copy of the posting.
What we verified
- The pay figures come from the employer's own listing, quoted exactly above.
- The pay is an annual base salary in US dollars with a minimum of at least $100,000.
- The role was publicly listed on the employer's job board when last checked.
We do not verify what the employer will actually offer, whether the employer is still recruiting for the role, or anything beyond what the employer published. Full methodology.