Scientist, Metabolism
Company websitenewlimit.com (NewLimit, opens in new tab)
Base salary $130K to $165K
Employer-published annual base salary, USD. Advertised base range in South San Francisco, CA
You apply on the employer's own site. Six Figure Work does not handle applications.
- LocationSouth San Francisco, CA
- WorkplaceWorkplace not stated
- Status at last checkSource accepting applications when checked
- Last checked (2 h ago) · observed since
About this job
Company info
NewLimit is a biotechnology company working to radically extend human healthspan. We’re developing medicines to treat age-related diseases by reprogramming the epigenome, a new therapeutic mechanism to restore regenerative potential in aged and diseased cells. We leverage functional genomics, pooled perturbation screening, and machine learning models to unravel the biology of epigenetic aging and disease using experiments of unprecedented scale.
Description
NewLimit is seeking an scientist with experience in liver biology and metabolism to join our Metabolism team. Our Metabolism team is developing reprogramming medicines to restore youthful function in aged hepatocytes in the context of metabolic disease. In this role, you will develop and perform assays for hepatocyte function, contribute to team decision making, and serve as a subject matter expert within NewLimit to enable our therapeutic development efforts.
As a Scientist on our team, you will:
- Collaborate with our Single Cell Technology, Epigenetic Editing, and Predictive Modeling teams to design, build, and test epigenetic reprogramming interventions for aged and diseased hepatocytes
- Develop assays to preclinical models of liver disease to measure hepatocyte function
- Evaluate epigenetic reprogramming payloads using in vivo functional assays to select therapeutic candidates
- Deliver epigenetic reprogramming perturbations to hepatocytes in vivo using multiple transgenic manipulation methods (e.g. viral vectors, lipid nanoparticles)
- Analyze and interpret experimental data to drive pre-clinical decision making
Requirements
- Ph.D. in cell biology, molecular biology, biochemistry or a related field or equivalent industry experience (5+ years)
- Experience with primary liver cell isolation and functional characterization
- Experience working with mouse models of liver dysfunction
- Experience with transgenic manipulation of liver cells either ex vivo or in vivo (e.g. using viral vectors, nucleic acid delivery)
- Exceptional organizational skills, including detailed experimental record-keeping and the ability to manage multiple concurrent project
Nice to have
- History of contributing to a drug development program at the pre-clinical or clinical development stage
- Experience leading the design and execution of pre-clinical studies in mouse models
- Experience with single cell genomics methods
- Experience with pooled screening approaches using bulk or single cell read-outs (e.g. CRISPR fitness screens, Perturb/CROP-seq)
Benefits
NewLimit offers generous benefits to ensure our team can focus on our mission:
- Health, dental, and vision insurance
- 401(k) with company match
- Paid parental leave
- Industry-leading paid time off (PTO) — 20 days/year for all employees + holidays
- Meals and snacks on-site
Salary Range: $130,000 to $165,000. Compensation for the role will depend on a number of factors, including a candidate’s qualifications, skills, competencies, and experience. Learn more at: https://www.newlimit.com/careers
*This compensation and benefits information is based on Company's good faith estimate as of the date of publication and may be modified in the future
Source: NewLimit on Greenhouse · View original posting (opens in new tab)
Pay in context
This role's base floor ($130,000) is above 37% of the 320 Science & Research roles in California listed on this site; 4 others list the same floor. Their median floor is $143,200; the middle half runs from $120,000 to $172,100.
Only jobs on this site count, and each one publishes a base salary of $100,000 or more, so this compares six-figure jobs with each other, not with the whole market. Computed Nov 7, 2026.
This listingScientist, Metabolism$130K to $165K
Scientist/Senior Scientist, Immunology$130K to $180K
Scientist- Delivery Sciences-targeted LNPs (tLNPs)$130K to $171K
Senior Scientist / Scientist, In Vivo Pharmacology$130K to $180K
Scientist/Senior Scientist$130K to $180K
Scientist, mRNA Downstream PurificationFrom $120K
Scientist, mRNA Analytical DevelopmentFrom $120K
Chart as a table
| Role | Published base |
|---|---|
| Scientist, Metabolism (this listing) | $130K - $165K |
| Scientist/Senior Scientist, Immunology | $130K - $180K |
| Scientist- Delivery Sciences-targeted LNPs (tLNPs) | $130K - $171K |
| Senior Scientist / Scientist, In Vivo Pharmacology | $130K - $180K |
| Scientist/Senior Scientist | $130K - $180K |
| Scientist, mRNA Downstream Purification | From $120K |
| Scientist, mRNA Analytical Development | From $120K |
Observed changes
- First observed on the employer's board
- Began meeting the published-salary criteria
- Observed since
- Employer-stated posting date
- 2026-09-25
Where this pay comes from
Location as the employer wrote it: South San Francisco
Salary Range: $130,000 to $165,000. Compensation for the role will depend on a number of facto
- Method
- Employer text, read with fixed rules and re-verified
- Checked
- Rule set
- us-base-v2
The pay passage appears in the employer's own job text. Fixed, deterministic rules located it, and the passage below was checked against the stored copy of the posting.
What we verified
- The pay figures come from the employer's own listing, quoted exactly above.
- The pay is an annual base salary in US dollars with a minimum of at least $100,000.
- The role was publicly listed on the employer's job board when last checked.
We do not verify what the employer will actually offer, whether the employer is still recruiting for the role, or anything beyond what the employer published. Full methodology.