Senior/Principal Scientist, Computational Neuroscience, Computational Sciences Center of Excellence
Company websiteroche.com (Roche, opens in new tab)
Base salary From $144,900
Employer-published annual base salary, USD. Advertised base range in United States
You apply on the employer's own site. Six Figure Work does not handle applications.
- LocationUnited States
- WorkplaceWorkplace not stated
- Status at last checkSource accepting applications when checked
- Last checked (1 h ago) · observed since
About this job
A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Roche.
Advances in AI, data, and computational sciences are transforming drug discovery and development. Roche’s Research and Early Development organisations at Genentech (gRED) and Pharma (pRED) have demonstrated how these technologies accelerate R&D, leveraging data and novel computational models to drive impact. Seamless data sharing and access to models across gRED and pRED are essential to maximising these opportunities. The Computational Sciences Center of Excellence (CoE) is a strategic, unified group whose goal is to harness this transformative power of data and Artificial Intelligence (AI) to assist our scientists in delivering more innovative and transformative medicines for patients worldwide.
We seek a creative and highly accomplished scientist to develop and execute Genentech/Roche’s Foundational Data and Models strategy in Computational Neuroscience, helping to deliver new treatments for neurodegenerative and neuroinflammatory diseases such as Alzheimer’s, Parkinson’s, ALS and multiple sclerosis, in the department of Computational Biology & Medicine within the Roche Computational Sciences Center of Excellence (CS-CoE).
The Opportunity:
Working within and extending Roche’s existing data ecosystems to accelerate our Neuroscience portfolio.
Developing strategy to effectively mine large data and drive science using LLMs, advanced automation and AI agents.
Analysis and integration of human genetic, single-cell atlases, perturbation and other data types to derive novel insights into the pathobiology of neurodegenerative and neuroinflammatory diseases.
Nomination of new entries to Neuroscience department Target Assessment Portfolio and identification of new biomarkers for existing therapeutic programs.
Serving as computational lead on pipeline programs, supporting target validation, mechanism of action, safety and biomarker studies
Who You Are:
PhD or equivalent with in-depth training in a relevant field, and deep understanding of both biological pathways relevant to neurodegeneration/neuroimmunology and computational methods to study these pathways (Senior Scientist). Additionally, successful postdoctoral research or ≥3 years equivalent experience after PhD (Principal Scientist).
The ideal candidate will have deep experience in many of the following types of analysis:
Perturb-seq and related CRISPR screening
Patient tissue or CSF/PBMC atlases
Use of human genetics to prioritize drug targets
Familiarity with AI approaches and AI agents to enable scientific insights
A track record of impactful scientific achievement, which may be demonstrated by co-first/lead as well as contributing author publications
Excellent communication skills and evidence of success in complex, multidisciplinary environments
Onsite presence, on our South San Francisco campus, is expected for at least 3 days a week.
Relocation benefits will be available for this posting.
The expected salary range for this position based on the primary location of South San Francisco, California is $144,900 - $269,100 (Senior Scientist) and $161,000 - $299,000 (Principal Scientist). Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
#LI-JD1
#ComputationCoE
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
Source: Roche on Workday · View original posting (opens in new tab)
Pay in context
This role's base floor ($144,900) is above 51% of the 320 Science & Research roles in California listed on this site. Their median floor is $143,200; the middle half runs from $120,000 to $172,100.
Only jobs on this site count, and each one publishes a base salary of $100,000 or more, so this compares six-figure jobs with each other, not with the whole market. Computed Nov 7, 2026.
This listingSenior/Principal Scientist, Computational Neuroscience, Computational Sciences Center of ExcellenceFrom $144,900
Software Engineer$143,800 to $267,000
Senior Corporate Counsel$146,300 to $271,700
Contract Strategy Implementation Director$146,500 to $272,100
Global Clinical Program Lead$146,600 to $272,200
R&D Business Insight and Digital Solution Lead$143,400 to $266,200
Principal Scientist - Oligonucleotide Design and Chemistry$143,200 to $266,000
Chart as a table
| Role | Published base |
|---|---|
| Senior/Principal Scientist, Computational Neuroscience, Computational Sciences Center of Excellence (this listing) | From $144,900 |
| Software Engineer | $143,800 - $267,000 |
| Senior Corporate Counsel | $146,300 - $271,700 |
| Contract Strategy Implementation Director | $146,500 - $272,100 |
| Global Clinical Program Lead | $146,600 - $272,200 |
| R&D Business Insight and Digital Solution Lead | $143,400 - $266,200 |
| Principal Scientist - Oligonucleotide Design and Chemistry | $143,200 - $266,000 |
Observed changes
- First observed on the employer's board
- Began meeting the published-salary criteria
- Observed since
- Employer-stated posting date
- 2026-09-01
Where this pay comes from
Location as the employer wrote it: US (regional bands)
The expected salary range for this position based on the primary location of South San Francisco, California is $144,900 - $269,100 (Senior Scientist) and $161,000 - $299,000 (Principal Scien
- Method
- Employer text, read with fixed rules and re-verified
- Checked
- Rule set
- us-base-v2
The pay passage appears in the employer's own job text. Fixed, deterministic rules located it, and the passage below was checked against the stored copy of the posting.
What we verified
- The pay figures come from the employer's own listing, quoted exactly above.
- The pay is an annual base salary in US dollars with a minimum of at least $100,000.
- The role was publicly listed on the employer's job board when last checked.
We do not verify what the employer will actually offer, whether the employer is still recruiting for the role, or anything beyond what the employer published. Full methodology.