Senior Director, Nonclinical Toxicology
Company websitenurixtx.com (Nurix, opens in new tab)
Base salary $312,900 to $344,900
Employer-published annual base salary, USD. Advertised base range in Brisbane, CA
You apply on the employer's own site. Six Figure Work does not handle applications.
- LocationBrisbane, CA
- WorkplaceWorkplace not stated
- Status at last checkSource accepting applications when checked
- Last checked (36 min ago) · observed since
About this job
Senior Director, Nonclinical Toxicology
Lead toxicology strategy across discovery, preclinical and clinical development at Nurix. As Senior Director, Nonclinical Toxicology, you’ll guide exploratory and GLP safety studies, assess the human risk of novel therapeutic targets, and help shape the regulatory documents that support global clinical development.
Position Description
The Opportunity
- Design and management of exploratory and GLP toxicology and safety pharmacology studies. Handle multiple projects in a timely and effective manner at various stages of discovery, preclinical, and clinical development. Write, interact, and/or contribute to all applicable Regulatory Documents/Authorities and Asset Teams.
- Lead toxicology strategy and tactics in discovery, preclinical development and clinical development with a focus on understanding/assessing the human risk of novel therapeutic targets and/or understanding mode of action for toxicity in nonclinical studies
- Participate in multi-disciplinary team efforts and implement program-specific toxicology strategies to support compound and program progression
- Monitor outsourced GLP and non-GLP studies ensuring compliance with the protocol, amendments, regulations, safety guidelines, and standard operating procedures
- Write and review toxicology protocols, reports, and documentation for regulatory filings, and participate in regulatory interactions
- Apply a broad understanding of toxicology, pharmacology, ADME, and knowledge of applicable regulatory guidelines to the design of appropriate toxicology studies and development plans
- Provide creative approaches to expedite nonclinical development strategies
- Provide a critical review of toxicology study protocols, data and study reports
- Serve as the Toxicology representative on multi-functional project teams supporting discovery and development phase projects
- Contribute to the preparation of high-quality regulatory documents supporting global clinical development and marketing authorizations
- Effectively communicate toxicology study results to project teams and senior level management
- Travel required as needed
What You’ll Bring
Required Qualifications
- D. in Toxicology, Pharmacology, or a related field with a minimum of 10 years, or M.S. degree with a minimum of 15 years, of pharmaceutical or biotechnology industry experience as part of a drug development project team
- Extensive experience in discovery and development of small molecules, degraders, and antibody drug conjugates is desirable
- Experience in designing, monitoring and interpreting nonclinical toxicology/safety pharmacology studies
- Experience in writing and reviewing nonclinical sections of regulatory documents (CTA, IND, IB, NDA, BLA, etc.) and direct interactions with worldwide regulatory agencies
- Extensive drug development experience with strong decision making and problem-solving skills
- Excellent written and verbal communication skills, which includes ability to communicate complex toxicology and safety issues clearly to key stakeholders
- Experience in health-authority interactions and developing regulatory strategies that require a high degree of scientific and strategic judgments
- Competency in incorporating the use of NAMs in toxicological evaluations to strengthen translational decision making
Bonus Qualifications
- Board certification in toxicology is highly desired
Salary Range: $ 312,900 - $344,900
The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.
Location: Onsite – Brisbane, CA
Fit with Nurix Culture and Values
- Strong team orientation; highly collaborative
- Solutions and results-oriented focus
- Hands-on approach; resourceful and open to diverse points of view
About Nurix Therapeutics
Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.
Source: Nurix on Greenhouse · View original posting (opens in new tab)
Pay in context
This role's base floor ($312,900) is above 97% of the 492 Science & Research roles in California listed on this site. Their median floor is $159,477; the middle half runs from $126,066 to $200,000.
Only jobs on this site count, and each one publishes a base salary of $100,000 or more, so this compares six-figure jobs with each other, not with the whole market. Computed Nov 7, 2026.
This listingSenior Director, Nonclinical Toxicology$312,900 to $344,900
Senior Director, Quality Control$280,200 to $319,800
Director, IT Infrastructure & Operations$260K to $300K
Director, Total Rewards$250,800 to $278,800
Director, Quality Compliance and Supplier Quality$243,900 to $262,600
Director, Head of Investigative Toxicology$240,100 to $281,700
Director, Quality Assurance$228,100 to $252,000
Chart as a table
| Role | Published base |
|---|---|
| Senior Director, Nonclinical Toxicology (this listing) | $312,900 - $344,900 |
| Senior Director, Quality Control | $280,200 - $319,800 |
| Director, IT Infrastructure & Operations | $260K - $300K |
| Director, Total Rewards | $250,800 - $278,800 |
| Director, Quality Compliance and Supplier Quality | $243,900 - $262,600 |
| Director, Head of Investigative Toxicology | $240,100 - $281,700 |
| Director, Quality Assurance | $228,100 - $252,000 |
Observed changes
- Began meeting the published-salary criteria
- First observed on the employer's board
- Observed since
- Employer-stated posting date
- 2026-11-05
Where this pay comes from
Location as the employer wrote it: Brisbane, California
Salary Range: $ 312,900 - $344,900
- Method
- Employer text, read with fixed rules and re-verified
- Checked
- Rule set
- us-base-v2
The pay passage appears in the employer's own job text. Fixed, deterministic rules located it, and the passage below was checked against the stored copy of the posting.
What we verified
- The pay figures come from the employer's own listing, quoted exactly above.
- The pay is an annual base salary in US dollars with a minimum of at least $100,000.
- The role was publicly listed on the employer's job board when last checked.
We do not verify what the employer will actually offer, whether the employer is still recruiting for the role, or anything beyond what the employer published. Full methodology.