Scientist I, Bioanalytical
Company websitenurixtx.com (Nurix, opens in new tab)
Base salary $141,500 to $175,600
Employer-published annual base salary, USD. Advertised base range in Brisbane, CA
You apply on the employer's own site. Six Figure Work does not handle applications.
- LocationBrisbane, CA
- WorkplaceWorkplace not stated
- Status at last checkSource accepting applications when checked
- Last checked (2 h ago) · observed since
About this job
Scientist I, Bioanalytical
Help drive Nurix’s drug discovery programs by turning complex biological samples into the high-quality bioanalytical data that guides decisions. You will develop and run LC-MS/MS assays for targeted protein degrader candidates and work closely with pharmacology, chemistry and biology teams.
Position Description
Nurix Therapeutics is searching for a motivated Scientist I to join our Bioanalytical team. The successful candidate will contribute to the bioanalytical efforts to support Nurix drug discovery programs involving in vivo and in vitro studies. The primary responsibility will be to conduct quantitative bioanalysis for in vivo samples. The scope of the daily responsibilities for this position includes, but is not limited to, developing bioanalytical methods, quantitating drug candidates and their metabolites, endogenous biomarkers in biological matrix (e.g. blood, plasma, tissues, tumor, CSF, etc.), and reporting high-quality data. The successful candidate will have extensive experience in bioanalytical method development and sample analysis using LC-MS/MS and other analytical techniques.
The Opportunity
- Provide bioanalytical support for in vivo PK, PK/PD, efficacy studies, non-GLP toxicology and in vitro studies
- Conduct bioanalytical method development and qualification to support drug, metabolite and biomarker analysis
- Independently develop LC-MS/MS methods to quantitate small molecules in in vitro and in vivo samples and execute sample analysis
- Independently operate, troubleshoot and maintain LC-MS/MS and analytical equipment
- Participate in multidisciplinary project teams and partner closely with other departments, including pharmacology, chemistry and biology to understand bioanalytical needs for PK support
- Maintain accurate and detailed laboratory notebooks
- Ability to think and plan strategically, and excellent interpersonal skills and ability to work in a team environment
What You’ll Bring
- BS or equivalent with 10 or more years’ relevant experience, or MS with 6 or more years’ relevant experience, or PhD with up to 4 years’ relevant experience working in a discovery setting using quantitative LC-MS/MS within a pharmaceutical or biotechnology company
- Demonstrated experience in small molecule biomarkers as well as drug candidate bioanalytical assay development/sample quantitative analysis in complex biological matrices using LC-MS/MS
- Proven experience running and troubleshooting LC-MS/MS-based quantitative workflows on Sciex platforms and software
- Excellent written, verbal communications and interpersonal skills to collaborate with internal and external partners in a matrix environment
- Ability to work in a fast-paced, collaborative environment and manage multiple priorities
Preferred Qualifications
- Experience in targeted protein degradation or heterobifunctional degrader platforms
- Extensive experience with H/UPLC and mass spectrometry
- Extensive experience with sample analysis to support PK, PK/PD, efficacy, distribution, metabolism, and non-GLP toxicology studies
- Extensive experience in developing and implementing quantitative LC-MS/MS based assays for small molecules in complex biological matrices
- Excellent oral and written communication skills
- Experience reviewing result files and reports from bioanalytical contract research organizations
- Experience with maintaining detailed up to date lab notebooks and technical documentation
Location: Onsite – Brisbane, CA
Salary Range: $141,500 - $175,600
The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.
Fit with Nurix Culture and Values
- Strong team orientation; highly collaborative
- Solutions and results-oriented focus
- Hands-on approach; resourceful and open to diverse points of view
About Nurix Therapeutics
Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.
Source: Nurix on Greenhouse · View original posting (opens in new tab)
Pay in context
This role's base floor ($141,500) is above 36% of the 492 Science & Research roles in California listed on this site; 2 others list the same floor. Their median floor is $159,477; the middle half runs from $126,066 to $200,000.
Only jobs on this site count, and each one publishes a base salary of $100,000 or more, so this compares six-figure jobs with each other, not with the whole market. Computed Nov 8, 2026.
This listingScientist I, Bioanalytical$141,500 to $175,600
Senior Scientist, Medicinal Chemistry$147,500 to $157,500
Senior Research Associate, Preclinical Pharmacology$131,400 to $139,900
Scientist I, Medicinal Chemistry$130,200 to $141,400
Senior Analyst, FP&A$130,000 to $158,900
Scientist I, Bioanalytical – Drug Antibody Conjugates (DACs)$123,800 to $143,100
Senior Manager, electronic Quality Management System (eQMS)$158,700 to $172,100
Chart as a table
| Role | Published base |
|---|---|
| Scientist I, Bioanalytical (this listing) | $141,500 - $175,600 |
| Senior Scientist, Medicinal Chemistry | $147,500 - $157,500 |
| Senior Research Associate, Preclinical Pharmacology | $131,400 - $139,900 |
| Scientist I, Medicinal Chemistry | $130,200 - $141,400 |
| Senior Analyst, FP&A | $130,000 - $158,900 |
| Scientist I, Bioanalytical – Drug Antibody Conjugates (DACs) | $123,800 - $143,100 |
| Senior Manager, electronic Quality Management System (eQMS) | $158,700 - $172,100 |
Observed changes
- First observed on the employer's board
- Began meeting the published-salary criteria
- Stopped meeting the published-salary criteria
- fields changed
- fields changed
- Began meeting the published-salary criteria
- Observed since
- Employer-stated posting date
- 2026-10-22
Where this pay comes from
Location as the employer wrote it: Brisbane, California
Salary Range: $141,500 - $175,600
- Method
- Employer text, read with fixed rules and re-verified
- Checked
- Rule set
- us-base-v2
The pay passage appears in the employer's own job text. Fixed, deterministic rules located it, and the passage below was checked against the stored copy of the posting.
What we verified
- The pay figures come from the employer's own listing, quoted exactly above.
- The pay is an annual base salary in US dollars with a minimum of at least $100,000.
- The role was publicly listed on the employer's job board when last checked.
We do not verify what the employer will actually offer, whether the employer is still recruiting for the role, or anything beyond what the employer published. Full methodology.