Senior Director, Quality Control
Company websitenurixtx.com (Nurix, opens in new tab)
Base salary $280,200 to $319,800
Employer-published annual base salary, USD. Advertised base range in Brisbane, CA
You apply on the employer's own site. Six Figure Work does not handle applications.
- LocationBrisbane, CA
- WorkplaceWorkplace not stated
- Status at last checkSource accepting applications when checked
- Last checked (14 min ago) · observed since
About this job
Senior Director, Quality Control
Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.
Position Description
Nurix Therapeutics is seeking an experienced Senior Director, Quality Control to join the Analytical Development and Quality Control group. This individual will establish and lead a QC operational function, establishing operations, systems, and a team to support programs from CMC development through commercial manufacturing.
The ideal candidate brings deep expertise in small molecule QC, strong regulatory acumen, and proven experience managing external CDMO and CTL relationships. This role will represent QC in health authority inspections and audits, and will work cross-functionally with Quality, Analytical Development, and Manufacturing to ensure product quality and patient safety across the portfolio.
Key responsibilities
- Build and lead the QC function: Establish QC systems and infrastructure; recruit, manage, and mentor internal QC staff and contractors
- Set QC strategy across the product lifecycle: Define and execute QC strategy spanning CMC development through commercial programs, ensuring alignment with company milestones and submission timelines
- Oversee QC operations internally and externally: Direct method validation, release and stability testing, data review, deviations, investigations, change control, and CAPA internally and at CDMOs, and CTLs
- Identify and manage quality risk: Proactively identify, assess, and escalate risks related to patient safety, product quality, shelf life, supply continuity, or GMP compliance; drive risk mitigation strategies in partnership with Analytical Development, Quality, and Manufacturing functions
- Lead QC through audits and inspections: Serve as QC lead during health authority inspections and internal audits; collaborate with Quality to conduct audits of GMP manufacturing and testing sites, including CDMOs and CTLs
- Support regulatory submissions and health authority interactions: Contribute to global regulatory filings; collaborate on responses to health authority information requests, regulatory commitments, and post-approval changes
- Direct stability programs: Develop and execute stability strategy in collaboration with Analytical Development leads, ensuring alignment with ICH guidelines and regional regulatory requirements
- Manage reference materials and retains: Oversee qualification and inventory of reference standards; develop sampling plans and manage sample retain programs
- Drive continuous improvement: Identify and implement process improvements, data integrity enhancements, and quality system upgrades (e.g., eQMS) to support a scalable, inspection-ready QC organization
- Travel up to 15% to CDMO, CTL, and manufacturing sites and supplier and scientific conferences
Qualifications
- Advanced degree in Chemistry, Pharmaceutics, Chemical Engineering, or related discipline. BS/MS with 16+ years of relevant experience, or PhD with 14+ years of relevant experience
- 5+ years in a QC leadership or management role, with demonstrated ability to build and mentor teams
- Deep experience in small molecule pharmaceutical development, including method lifecycle management and oversight of validation, release, and stability operations
- Proven experience managing external manufacturing and testing operations at CDMOs and CTLs
- Expertise with analytical methods such as HPLC, GC, dissolution, and microbiological testing
- Direct experience leading through health authority inspections and internal audits and conducting audits of manufacturing and testing sites.
- Deep working knowledge of cGMP, ICH guidelines, and USP/EP/JP compendial standards
- Experience contributing to global regulatory filings and health authority correspondence (e.g., responses to information requests, post-approval changes)
- Strong interpersonal and cross-functional collaboration skills, with the ability to influence and build consensus across Quality, Supply Chain, Analytical Development, and Manufacturing functions
Fit with Nurix Culture and Values
- Strong team orientation; highly collaborative
- Solutions and results-oriented focus
- Hands-on approach; resourceful and open to diverse points of view
Salary Range: $280,200 - $319,800
Location: Woodlands TX or Brisbane, CA - Onsite
Source: Nurix on Greenhouse · View original posting (opens in new tab)
This listingSenior Director, Quality Control$280,200 to $319,800
Director, IT Infrastructure & Operations$260K to $300K
Director, Total Rewards$250,800 to $278,800
Senior Director, Nonclinical Toxicology$312,900 to $344,900
Director, Quality Compliance and Supplier Quality$243,900 to $262,600
Director, Head of Investigative Toxicology$240,100 to $281,700
Director, Quality Assurance$228,100 to $252,000
Chart as a table
| Role | Published base |
|---|---|
| Senior Director, Quality Control (this listing) | $280,200 - $319,800 |
| Director, IT Infrastructure & Operations | $260K - $300K |
| Director, Total Rewards | $250,800 - $278,800 |
| Senior Director, Nonclinical Toxicology | $312,900 - $344,900 |
| Director, Quality Compliance and Supplier Quality | $243,900 - $262,600 |
| Director, Head of Investigative Toxicology | $240,100 - $281,700 |
| Director, Quality Assurance | $228,100 - $252,000 |
Observed changes
- Began meeting the published-salary criteria
- First observed on the employer's board
- Observed since
- Employer-stated posting date
- 2026-09-07
Where this pay comes from
Location as the employer wrote it: Brisbane, California, United States
Salary Range: $280,200 - $319,800
- Method
- Employer text, read with fixed rules and re-verified
- Checked
- Rule set
- us-base-v2
The pay passage appears in the employer's own job text. Fixed, deterministic rules located it, and the passage below was checked against the stored copy of the posting.
What we verified
- The pay figures come from the employer's own listing, quoted exactly above.
- The pay is an annual base salary in US dollars with a minimum of at least $100,000.
- The role was publicly listed on the employer's job board when last checked.
We do not verify what the employer will actually offer, whether the employer is still recruiting for the role, or anything beyond what the employer published. Full methodology.