Technical Development Principal Scientist, Mass Spectrometry Characterization Lead
Company websiteroche.com (Roche, opens in new tab)
Base salary $120,800 to $224,300
Employer-published annual base salary, USD. Advertised base range in South San Francisco, CA
You apply on the employer's own site. Six Figure Work does not handle applications.
- LocationSouth San Francisco, CA
- WorkplaceWorkplace not stated
- Status at last checkSource accepting applications when checked
- Last checked (13 min ago) · observed since
About this job
A healthier future. It’s what drives us to innovate. To continuously advance science and ensure everyone has access to the healthcare they need today and for generations to come. Creating a world where we all have more time with the people we love. That’s what makes us Genentech!
Join our global Analytical Development and Quality Control team as a Technical Development Principal Scientist, Mass Spectrometry Characterization Lead, driving analytical strategies that transform cutting-edge biologic therapeutics from early development to commercialization. In this role, you will bridge strategic leadership with hands-on laboratory expertise within a collaborative, multidisciplinary environment dedicated to delivering life-changing medicines. You will lead mass spectrometry characterization, solve complex analytical challenges, and guide cross-functional teams with scientific excellence and impact.
The Opportunity
- Lead the mass spectrometry (MS) characterization strategy and execution across all stages of biologic therapeutic development, from early development through to commercial launch.
- Design, execute, and interpret complex liquid chromatography-mass spectrometry (LC-MS) analyses to establish deep structural understanding of protein modalities and resolve technical root causes.
- Develop and implement phase-appropriate MS methods and advanced multi-attribute method (MAM) strategies where standard analytical assays fall short.
- Identify, monitor, and quantify critical quality attributes (CQAs) and post-translational modifications (PTMs) to ensure reliable analytical control.
- Support process development milestones, including cell line selection, purification, formulation, stability, minor variant characterization, and structure-function elucidation.
- Author filing-ready MS characterization sections for global regulatory submissions (IND, BLA, and MAA) and represent technical packages in regulatory interactions.
- Collaborate closely with multidisciplinary teams, analytical leads, and external research/manufacturing partners to achieve project delivery milestones.
- Mentor scientific team members in MS data interpretation and champion modern analytical capabilities and best practices.
Who you are
- You hold a Ph.D. with 4–6+ years of relevant experience, or an M.S./B.S. with 6–10+ years of experience in Analytical Chemistry, Biochemistry, Chemical Engineering, or a related field.
- You bring deep analytical expertise in liquid chromatography-mass spectrometry (LC-MS) applied to the characterization of proteins or related therapeutic modalities.
- You possess strong working knowledge of chemistry, manufacturing, and controls (CMC) drug development and regulatory filing processes (IND/BLA).
- You demonstrate excellent collaborative, organizational, and communication skills, thriving both as an independent lead and as part of a dynamic, multidisciplinary team.
- You are an agile problem-solver motivated by scientific curiosity, technical quality, and delivering meaningful results in a fast-paced environment.
Relocation benefits are available for this job posting.
The expected salary range for this position based on the primary location of South San Francisco, CA is $120,800 - $224,300. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance. This position also qualifies for the benefits detailed at the link provided below.
Benefits
Genentech is an equal opportunity employer. It is our policy and practice to employ, promote, and otherwise treat any and all employees and applicants on the basis of merit, qualifications, and competence. The company's policy prohibits unlawful discrimination, including but not limited to, discrimination on the basis of Protected Veteran status, individuals with disabilities status, and consistent with all federal, state, or local laws.
If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form Accommodations for Applicants.
Source: Roche on Workday · View original posting (opens in new tab)
Pay in context
This role's base floor ($120,800) is above 26% of the 321 Science & Research roles in California listed on this site; 2 others list the same floor. Their median floor is $143,200; the middle half runs from $120,000 to $172,100.
Only jobs on this site count, and each one publishes a base salary of $100,000 or more, so this compares six-figure jobs with each other, not with the whole market. Computed Nov 7, 2026.
This listingTechnical Development Principal Scientist, Mass Spectrometry Characterization Lead$120,800 to $224,300
Senior Manager, QC Chemistry and Device Testing (CVRM)$120,100 to $223,100
Principal Project Scheduler$119,900 to $222,700
Associate Program Director, Commercial Regulatory Affairs (CORA)$120,200 to $223,200
Scientist 3 – Translational Medicine, Oncology$120,700 to $224,100
Senior Scientist- Translational PKPD$120,700 to $224,100
Technical Development Principal Scientist / Engineer$120,800 to $224,300
Chart as a table
| Role | Published base |
|---|---|
| Technical Development Principal Scientist, Mass Spectrometry Characterization Lead (this listing) | $120,800 - $224,300 |
| Senior Manager, QC Chemistry and Device Testing (CVRM) | $120,100 - $223,100 |
| Principal Project Scheduler | $119,900 - $222,700 |
| Associate Program Director, Commercial Regulatory Affairs (CORA) | $120,200 - $223,200 |
| Scientist 3 – Translational Medicine, Oncology | $120,700 - $224,100 |
| Senior Scientist- Translational PKPD | $120,700 - $224,100 |
| Technical Development Principal Scientist / Engineer | $120,800 - $224,300 |
Observed changes
- First observed on the employer's board
- Began meeting the published-salary criteria
- Observed since
- Employer-stated posting date
- 2026-11-05
Where this pay comes from
Location as the employer wrote it: South San Francisco
The expected salary range for this position based on the primary location of South San Francisco, CA is $120,800 - $224,300. Actual pay will be determined based on experience, qualifi
- Method
- Employer text, read with fixed rules and re-verified
- Checked
- Rule set
- us-base-v2
The pay passage appears in the employer's own job text. Fixed, deterministic rules located it, and the passage below was checked against the stored copy of the posting.
What we verified
- The pay figures come from the employer's own listing, quoted exactly above.
- The pay is an annual base salary in US dollars with a minimum of at least $100,000.
- The role was publicly listed on the employer's job board when last checked.
We do not verify what the employer will actually offer, whether the employer is still recruiting for the role, or anything beyond what the employer published. Full methodology.