Senior Scientist, Medicinal Chemistry
Company websitenurixtx.com (Nurix, opens in new tab)
Base salary $147,500 to $157,500
Employer-published annual base salary, USD. Advertised base range in The Woodlands, TX
You apply on the employer's own site. Six Figure Work does not handle applications.
- LocationThe Woodlands, TX
- WorkplaceWorkplace not stated
- Status at last checkSource accepting applications when checked
- Last checked (1 h ago) · observed since
About this job
Senior Scientist, Medicinal Chemistry
Drive medicinal chemistry strategy for Nurix's discovery programs, from hit optimization through development candidate nomination. You'll design novel compounds, interpret complex SAR across multidisciplinary datasets, and help set new scientific directions, with opportunities to lead chemistry workstreams and mentor colleagues.
Position Description
The Opportunity
- Design novel chemical entities and medicinal chemistry strategies, applying structure-based drug design to optimize potency, selectivity, physicochemical properties, ADME/PK, safety, and in vivo efficacy
- Design synthetic strategies for complex molecules using modern and creative synthetic methods
- Develop and interpret SAR by integrating chemical, structural, computational, biochemical, cellular, pharmacological, and ADME/PK data; independently identify key questions, design experiments, and recommend compound or series advancement, redesign, or termination
- Partner closely with computational chemists, structural biologists, and colleagues across biology, pharmacology, and DMPK to advance project objectives
- Develop innovative concepts that establish new directions and address complex challenges, drawing on emerging literature, patents, and competitive intelligence to inform compound design and strategy
- Lead chemistry workstreams within multidisciplinary teams, independently manage priorities and external collaborations, and contribute to project strategy and key scientific decisions
- Provide scientific guidance, coaching, and mentorship to other scientists
- Communicate scientific rationale, data, and recommendations clearly to project teams, leadership, and broader scientific audiences
- Contribute to intellectual property generation, patent preparation, and scientific publications; represent assigned projects at external forums; and lead improvements in laboratory practices and workflows
What You’ll Bring
- BS or MS with 14+ years of relevant experience, or PhD with 8+ years of relevant experience
- Strong expertise in medicinal chemistry and synthetic organic chemistry, with demonstrated ability to apply synthetic strategies to complex discovery challenges, including compound design, SAR development, multiparameter optimization, and structure-based drug design in close collaboration with computational chemistry and structural biology
- Ability to integrate potency, selectivity, structural, physicochemical, ADME/PK, and pharmacology data, with a solid understanding of biology and pharmacology, to guide compound design and project strategy
- Scientific creativity and a track record of innovation, including advancement of chemical series, advanced leads, or development candidates
- Strong problem-solving and project management skills: identifying critical questions, forming hypotheses, designing experiments, and translating results into actionable strategies across projects of significant scope and complexity
- Ability to establish new chemical, scientific, or strategic directions from experimental data, structural insights, literature, patents, and emerging science, and to influence decisions within multidisciplinary teams
- Experience providing scientific guidance, coaching, or mentorship, with strong skills in applying literature, patent, and competitive intelligence to program strategy
- Excellent written and verbal communication skills for multidisciplinary teams, senior leadership, and external audiences
Salary Range: $147,500 - $157,500
The posted range applies to roles based in The Woodlands, TX area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.
Location: Onsite – The Woodlands, TX
Fit with Nurix Culture and Values
- Strong team orientation; highly collaborative
- Solutions and results-oriented focus
- Hands-on approach; resourceful and open to diverse points of view
About Nurix Therapeutics
Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.
Source: Nurix on Greenhouse · View original posting (opens in new tab)
Pay in context
This role's base floor ($147,500) is above 43% of the 39 Science & Research roles in Texas listed on this site. Their median floor is $151,100; the middle half runs from $130,000 to $171,172.
Only jobs on this site count, and each one publishes a base salary of $100,000 or more, so this compares six-figure jobs with each other, not with the whole market. Computed Nov 8, 2026.
This listingSenior Scientist, Medicinal Chemistry$147,500 to $157,500
Scientist I, Bioanalytical$141,500 to $175,600
Senior Manager, electronic Quality Management System (eQMS)$158,700 to $172,100
Senior Manager, Analytical Development and Quality Control - Drug Product$161,100 to $185,600
Senior Scientist, Analytical Development and Quality Control - Early Phase$162K to $186K
Executive Business Partner$163,700 to $180,538
Senior Research Associate, Preclinical Pharmacology$131,400 to $139,900
Chart as a table
| Role | Published base |
|---|---|
| Senior Scientist, Medicinal Chemistry (this listing) | $147,500 - $157,500 |
| Scientist I, Bioanalytical | $141,500 - $175,600 |
| Senior Manager, electronic Quality Management System (eQMS) | $158,700 - $172,100 |
| Senior Manager, Analytical Development and Quality Control - Drug Product | $161,100 - $185,600 |
| Senior Scientist, Analytical Development and Quality Control - Early Phase | $162K - $186K |
| Executive Business Partner | $163,700 - $180,538 |
| Senior Research Associate, Preclinical Pharmacology | $131,400 - $139,900 |
Observed changes
- First observed on the employer's board
- Began meeting the published-salary criteria
- Observed since
- Employer-stated posting date
- 2026-10-13
Where this pay comes from
Location as the employer wrote it: The Woodlands, Texas
Salary Range: $147,500 - $157,500
- Method
- Employer text, read with fixed rules and re-verified
- Checked
- Rule set
- us-base-v2
The pay passage appears in the employer's own job text. Fixed, deterministic rules located it, and the passage below was checked against the stored copy of the posting.
What we verified
- The pay figures come from the employer's own listing, quoted exactly above.
- The pay is an annual base salary in US dollars with a minimum of at least $100,000.
- The role was publicly listed on the employer's job board when last checked.
We do not verify what the employer will actually offer, whether the employer is still recruiting for the role, or anything beyond what the employer published. Full methodology.