Scientist I, Medicinal Chemistry
Company websitenurixtx.com (Nurix, opens in new tab)
Base salary $130,200 to $141,400
Employer-published annual base salary, USD. Advertised base range in The Woodlands, TX
You apply on the employer's own site. Six Figure Work does not handle applications.
- LocationThe Woodlands, TX
- WorkplaceWorkplace not stated
- Status at last checkSource accepting applications when checked
- Last checked (1 h ago) · observed since
About this job
Scientist I, Medicinal Chemistry
Join Nurix's medicinal chemistry group to design and synthesize novel small molecules for patients with unmet medical needs. You'll apply structure-based drug design, supported by our computational and structural biology teams, as part of a dynamic, multidisciplinary project team.
Position Description
The Opportunity
- Design and synthesize novel chemical entities optimized for potency, selectivity, pharmacokinetics, and in vivo efficacy, using modern synthetic methods and creative strategies to access challenging molecules
- Engage in rational structure-based drug discovery enabled by our computational and structural biology group
- Apply strong problem-solving skills to troubleshoot challenges and identify practical solutions
- Design and execute high-quality experiments, critically analyze results, and use data to form hypotheses and guide next steps
- Advance structure-activity relationship (SAR) studies by contributing to compound design
- Collaborate with scientists in computational chemistry, structural biology, biochemistry and biophysics, cellular biology, pharmacology, DMPK, and toxicology, as well as external collaborators, to integrate multidisciplinary data and advance project objectives
- Stay current with advances in synthetic and medicinal chemistry and apply relevant methods to project work
- Communicate scientific rationale, results, challenges, and recommendations clearly to chemistry colleagues and cross-functional project teams
What You’ll Bring
- PhD with up to 4 years of relevant experience, MS with 6 or more years of relevant experience, or BS or equivalent with 10 or more years of relevant experience
- Strong expertise in synthetic organic chemistry, with demonstrated ability to design and execute complex, multistep organic synthesis
- Strong scientific and synthetic problem-solving skills and the ability to independently troubleshoot challenging chemistry
- Scientific curiosity, creativity, and the ability to rapidly learn and apply new concepts, technologies, and approaches
- Strong interpersonal and teamwork skills, with demonstrated ability to contribute in a collaborative, multidisciplinary research environment
- Excellent written and verbal communication skills, with the ability to clearly communicate scientific concepts, results, and conclusions
- Knowledge of medicinal chemistry principles, structure-based drug design, pharmacology, and/or ADME/PK, consistent with prior experience
Salary Range: $130,200 - $141,400
The posted range applies to roles based in The Woodlands, TX area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.
Location: Onsite – The Woodlands, TX
Fit with Nurix Culture and Values
- Strong team orientation; highly collaborative
- Solutions and results-oriented focus
- Hands-on approach; resourceful and open to diverse points of view
About Nurix Therapeutics
Nurix Therapeutics is a clinical stage biopharmaceutical company focused on the discovery, development, and commercialization of targeted protein degradation medicines, the next frontier in innovative drug design aimed at improving treatment options for patients with cancer and inflammatory diseases. Powered by a fully AI-integrated discovery engine capable of tackling any protein class, and coupled with unparalleled ligase expertise, Nurix’s dedicated team has built a formidable advantage in translating the science of targeted protein degradation into clinical advancements. Nurix aims to establish degrader-based treatments at the forefront of patient care, writing medicine’s next chapter with a new script to outmatch disease.
Source: Nurix on Greenhouse · View original posting (opens in new tab)
Pay in context
This role's base floor ($130,200) is above 43% of the 979 Science & Research roles nationwide listed on this site. Their median floor is $140,000; the middle half runs from $117,000 to $169,320.
Only jobs on this site count, and each one publishes a base salary of $100,000 or more, so this compares six-figure jobs with each other, not with the whole market. Computed Nov 7, 2026.
This listingScientist I, Medicinal Chemistry$130,200 to $141,400
Senior Analyst, FP&A$130,000 to $158,900
Senior Research Associate, Preclinical Pharmacology$131,400 to $139,900
Scientist I, Bioanalytical – Drug Antibody Conjugates (DACs)$123,800 to $143,100
Scientist I, Bioanalytical$141,500 to $175,600
Senior Scientist, Medicinal Chemistry$147,500 to $157,500
Senior Manager, electronic Quality Management System (eQMS)$158,700 to $172,100
Chart as a table
| Role | Published base |
|---|---|
| Scientist I, Medicinal Chemistry (this listing) | $130,200 - $141,400 |
| Senior Analyst, FP&A | $130,000 - $158,900 |
| Senior Research Associate, Preclinical Pharmacology | $131,400 - $139,900 |
| Scientist I, Bioanalytical – Drug Antibody Conjugates (DACs) | $123,800 - $143,100 |
| Scientist I, Bioanalytical | $141,500 - $175,600 |
| Senior Scientist, Medicinal Chemistry | $147,500 - $157,500 |
| Senior Manager, electronic Quality Management System (eQMS) | $158,700 - $172,100 |
Observed changes
- First observed on the employer's board
- Began meeting the published-salary criteria
- Observed since
- Employer-stated posting date
- 2026-10-13
Where this pay comes from
Location as the employer wrote it: The Woodlands, Texas
Salary Range: $130,200 - $141,400
- Method
- Employer text, read with fixed rules and re-verified
- Checked
- Rule set
- us-base-v2
The pay passage appears in the employer's own job text. Fixed, deterministic rules located it, and the passage below was checked against the stored copy of the posting.
What we verified
- The pay figures come from the employer's own listing, quoted exactly above.
- The pay is an annual base salary in US dollars with a minimum of at least $100,000.
- The role was publicly listed on the employer's job board when last checked.
We do not verify what the employer will actually offer, whether the employer is still recruiting for the role, or anything beyond what the employer published. Full methodology.