Senior Manager, Analytical Development and Quality Control - Drug Product
Company websitenurixtx.com (Nurix, opens in new tab)
Base salary $161,100 to $185,600
Employer-published annual base salary, USD. Advertised base range in Brisbane, CA
You apply on the employer's own site. Six Figure Work does not handle applications.
- LocationBrisbane, CA
- WorkplaceWorkplace not stated
- Status at last checkSource accepting applications when checked
- Last checked (3 h ago) · observed since
About this job
Senior Manager, Analytical Development and Quality Control – Drug Product
Lead drug product analytical development for Nurix’s oncology and inflammation & immunology programs, from method development through late-phase tech transfer, validation, and regulatory filings. You will guide CDMO and CRO partners and shape analytical and QC strategy for complex formulations, including amorphous solid dispersions and lipid-based systems, in close partnership with cross-functional teams.
Position Description
Nurix Therapeutics seeks an experienced Senior Manager to join the Analytical Development and Quality Control group. The Senior Manager will be responsible for drug product (DP) analytical development, including method development, oversight of method validation at CDMOs, and lifecycle management in support of Nurix’s oncology and inflammation & immunology (I&I) programs. The role provides technical oversight of analytical method development, validation, and testing at external CDMO/CRO partners, authors analytical development reports and IND/IMPD/NDA sections, supports late-phase tech transfer and validation activities, and contributes to analytical development for new drug products and dosage forms. The ideal candidate has expertise in chromatographic and dissolution method development, stability studies, and phase-appropriate validation and control strategies, along with demonstrated experience supporting late-phase development and regulatory submissions.
The Opportunity
- Lead analytical method development, validation, and lifecycle management for drug product formulations, including amorphous solid dispersions (ASDs) and lipid-based systems
- Support PPQ activities, commercialization, commercial QC, and lifecycle management for drug product analytical methods and control strategies
- Design and oversee DP development, registration batch, and commercial stability programs, including protocol development and trend analysis
- Author and review DP analytical development reports to support regulatory submissions and marketing authorization
- Oversee and support analytical activities, including method development, validation, and QC testing conducted at CDMOs and contract testing laboratories (CTLs)
- Contribute to investigations (e.g., OOS, OOE, OOT), root cause analysis, and CAPAs
- Perform critical review of analytical data, protocols, reports, specifications, and related documentation
- Trend stability data and support establishment of retest periods and shelf life using statistical methods
- Collaborate in the development and justification of material control strategies and specifications
- Author technical documents, including analytical development reports, specifications, validation and stability protocols/reports, certificates of analysis (COAs), and storage statements
- Author and review analytical sections of regulatory submissions (e.g., IND/IMPD/NDA)
- Collaboratively author responses to health authority requests for information
- Act as a key contributor to multidisciplinary teams, including Chemical Development, Pharmaceutical Development, Regulatory, Quality, Preclinical, Supply Chain, Medicinal Chemistry, and DMPK
- Maintain and organize analytical documentation and data to ensure traceability, data integrity, and inspection readiness
- Follow cGMP requirements and internal SOPs
- Travel up to 5%, as required
What You’ll Bring
- PhD in Chemistry, Pharmaceutics, or a related field with 8+ years of industrial CMC experience
- Strong experience in drug product analytical development and validation
- Experience with analytical development for amorphous solid dispersions (ASDs) and/or lipid-based formulations
- Experience in CDMO and contract testing lab oversight
- Experience supporting regulatory submissions (e.g., IND, IMPD, NDA) and global regulatory filings
- Fluency with ICH guidelines, cGMPs, and pharmacopeial chapters
- Ability to work effectively in a cross-functional environment
- Strong technical writing skills (e.g., development reports, regulatory documents)
- Ability to manage multiple priorities in a fast-paced environment
- Excellent communication and cross-functional collaboration skills
Salary Range: $161,100 - $185,600
The posted range applies to roles based in the San Francisco Bay Area and reflects local market conditions. Where an offer lands within that range depends on the candidate’s relevant experience, technical expertise, and how their background aligns with the role’s requirements.
Location: Onsite – Brisbane, CA
Fit with Nurix Culture and Values
- Strong team orientation; highly collaborative
- Solutions and results-oriented focus
- Hands-on approach; resourceful and open to diverse points of view
Source: Nurix on Greenhouse · View original posting (opens in new tab)
Pay in context
This role's base floor ($161,100) is above 52% of the 492 Science & Research roles in California listed on this site. Their median floor is $159,477; the middle half runs from $126,066 to $200,000.
Only jobs on this site count, and each one publishes a base salary of $100,000 or more, so this compares six-figure jobs with each other, not with the whole market. Computed Nov 7, 2026.
This listingSenior Manager, Analytical Development and Quality Control - Drug Product$161,100 to $185,600
Senior Manager, electronic Quality Management System (eQMS)$158,700 to $172,100
Senior Scientist, Analytical Development and Quality Control - Early Phase$162K to $186K
Executive Business Partner$163,700 to $180,538
Senior Scientist, Medicinal Chemistry$147,500 to $157,500
Scientist I, Bioanalytical$141,500 to $175,600
Senior Manager / Associate Director, Regulatory Affairs CMC (Small Molecules)$187,800 to $208,600
Chart as a table
| Role | Published base |
|---|---|
| Senior Manager, Analytical Development and Quality Control - Drug Product (this listing) | $161,100 - $185,600 |
| Senior Manager, electronic Quality Management System (eQMS) | $158,700 - $172,100 |
| Senior Scientist, Analytical Development and Quality Control - Early Phase | $162K - $186K |
| Executive Business Partner | $163,700 - $180,538 |
| Senior Scientist, Medicinal Chemistry | $147,500 - $157,500 |
| Scientist I, Bioanalytical | $141,500 - $175,600 |
| Senior Manager / Associate Director, Regulatory Affairs CMC (Small Molecules) | $187,800 - $208,600 |
Observed changes
- First observed on the employer's board
- Began meeting the published-salary criteria
- Observed since
- Employer-stated posting date
- 2026-05-13
Where this pay comes from
Location as the employer wrote it: Brisbane, CA
Salary Range: $161,100 - $185,600
- Method
- Employer text, read with fixed rules and re-verified
- Checked
- Rule set
- us-base-v2
The pay passage appears in the employer's own job text. Fixed, deterministic rules located it, and the passage below was checked against the stored copy of the posting.
What we verified
- The pay figures come from the employer's own listing, quoted exactly above.
- The pay is an annual base salary in US dollars with a minimum of at least $100,000.
- The role was publicly listed on the employer's job board when last checked.
We do not verify what the employer will actually offer, whether the employer is still recruiting for the role, or anything beyond what the employer published. Full methodology.